Table 1 Comparison of the top 25 terms of GO enrichment analysis and MeSH enrichment analysis results for the set of autophagy genes provided at GLAD
GO “Biological Process” enrichmentMeSH “Phenomena and Processes” enrichment
AutophagyAutophagy
larval midgut cell programmed cell deathGlycogenolysis
autophagosome assemblyCellular Microenvironment
GlycophagyProtein Interaction Maps
cellular response to starvationProtein Transport
MacroautophagyCell Survival
MitophagyMAP Kinase Signaling System
regulation of autophagyProteolysis
NucleophagyCell Size
protein phosphorylationCell Communication
cellular response to DNA damage stimulusEndocytosis
vesicle-mediated transportCell Death
cellular response to nitrogen starvationPhosphorylation
EndocytosisApoptosis
positive regulation of RNA polymerase II transcriptional preinitiation complex assemblyPhagocytosis
neuron remodelingGene Expression Regulation, Enzymologic
determination of adult lifespanProtein Processing, Post-Translational
regulation of growthLarva
regulation of cell growthDown-Regulation
ER-associated ubiquitin-dependent protein catabolic processUbiquitination
positive regulation of cell sizeLipid Metabolism
phosphatidylinositol dephosphorylationProtein Binding
Rab protein signal transductionMitosis
intra-Golgi vesicle-mediated transportAmino Acid Sequence
autophagosome maturationEnzyme Activation
  • Note: Terms shown in bold were found using both enrichment analysis methods; these might be similar terms with different wording, e.g., “Positive regulation of cell size” (GO term) and “Cell Size” (MeSH phenomena and process term). Each list is sorted in ascending order by enrichment P-values. GLAD, Gene List Annotation for Drosophila (https://www.flyrnai.org/tools/glad/).