Table 1 Significant and suggestive QTL for aortic and carotid atherosclerosis mapped in F2 mice derived from B6 and C3H Apoe−/− mice
Locus nameChrLODaPeak (cM)Closest marker95%CIbHigh alleleMode of inheritancecAllelic effectd
BBBCCC
Cath1013.5943.7D1Mit4532.7-57.7BAdditive17.7 ± 18.014.2 ± 14.98.4 ± 10.1
Cath253.4861.4D5Mit9539.4-71.4CDominant9.8 ± 14.215.2 ± 15.913.8 ± 13.9
Cath465.3328.1D6Mit24320.1-56.1BAdditive17.5 ± 18.213.6 ± 13.87.7 ± 10.7
Cath1183.4250.7D8Mit21132.7-55.7BDominant13.5 ± 13.014.5 ± 17.011.2 ± 12.9
Cath12103.4866.0D10Mit10349-70BDominant14.6 ± 14.514.7 ± 16.29.0 ± 10.9
Cath9113.8847.9D11Mit3640.9-54.9BAdditive17.8 ± 17.013.7 ± 14.77.5 ± 10.4
Cath1127.3924.0D12Mit28521-29BAdditive21.1 ± 19.013.0 ± 13.26.5 ± 8.3
Cath3134.3330.1D13Mit25017.9-38.9BAdditive18.1 ± 15.213.1 ± 15.38.9 ± 11.7
Ath3016.246.7D1Mit4539.9-55.8BAdditive97.2 ± 46.179.7 ± 45.857.3 ± 37.7
Ath119.4072.67D1Mit42565.7-86.7BAdditive105.6 ± 55.375.1 ± 37.848.3 ± 26.7
Ath4252.2737.35D5Mit3099.4-86.6BAdditive89.9 ± 55.676.8 ± 41.465.8 ± 45.8
Ath3172.9725.61D7Mit22817.1-65.2BAdditive95.5 ± 50.080.3 ± 48.160.6 ± 31.3
Ath2992.3832.80D9Mit26017.8-52.8BAdditive87.5 ± 46.280.2 ± 48.358.7 ± 32.2
Ath46112.4523.90D11Mit23612.9-56.9BRecessive90.4 ± 43.872.0 ± 46.975.1 ± 43.8
Ath21123.4446.00D12Mit23939.0-60.6BDominant83.6 ± 43.783.4 ± 45.659.4 ± 36.7
Ath22153.983.82D15Mit803.8-19.6CDominant61.0 ± 50.983.9 ± 44.080.0 ± 41.6
Ath16192.3148.46D19Mit1033.4-48.5Heterosis74.3 ± 39.586.3 ± 49.963.4 ± 39.6
  • a LOD scores were obtained from genome-wide QTL analysis using R/qtl. Significant QTL and LOD score were highlighted in bold. The suggestive and significant LOD score thresholds were defined by 1,000 permutation tests for the traits. Suggestive and significant LOD score thresholds for carotid atherosclerosis were 3.14 and 4.74, respectively. Suggestive and significant LOD score thresholds for aortic atherosclerosis were 2.13 and 3.58, respectively. b 95% Confidence interval in cM was estimated as the interval under the LOD curve after a 1.8-LOD unit drop from the peak. c Mode of inheritance was defined based on allelic effect of the nearest marker at a QTL. C: C3H allele; B: B6 allele. d Measurements for atherosclerosis are expressed as means ± SD in lesion size (µm2/section x 1000).