Table 1 List of 43 genes for which RNAi depletion caused elevated penetrance of the Pro phenotype in glp-1(ar202), but not in glp-1(+) in the liquid RNAi screen. Gene symbol, WormBase ID, linkage group, functional class, and results of the cognate RNAi on solid plates are shown for each gene. y, yes; n, no; nd, not determined
Gene SymbolWormBase IDLinkage GroupFunctional Class (manual)Functional Class NotesElevated Pro (solid)Altered DistalEnh(Pro) rrf-1-dependent
act-1WBGene00000063Vcytoskeletalnndnd
arf-1.2WBGene00000182IIImetabolismGTP binding activityyy
C23G10.5WBGene00016012IIIunknownnndnd
cct-7WBGene00020391Vproteostasisyy
cdk-12WBGene00007135IIItranscriptionphosphorylation of RNA polymerase IIynnd
cri-2WBGene00019478Vproteostasisnndnd
daf-1WBGene00000897IVsignalingnndnd
eif-3.FWBGene00001229IItranslationtranslation initiationyn
F25B5.3WBGene00017775IIImetabolismnndnd
F53F4.11WBGene00009993Vtranslationstructural component of ribosomeyn
F53H1.1WBGene00018776IVtranslationrRNA modification (helicase)ynnd
fib-1WBGene00001423VtranslationrRNA modification (methyltransferase)nndnd
H06I04.3WBGene00019168IIItranslationrRNA modification (methyltransferase)ynnd
hda-1WBGene00001834Vtranscriptionynnd
hoe-1WBGene00001983IVmetabolismendonuclease activity; metal ion binding activityynnd
iff-2WBGene00002065IItranslationtranslation initiationyy
knl-1WBGene00002231IIIcytoskeletalmicrotubule binding activityyy
mfap-1WBGene00009671ImRNA processingsplicingynnd
mrpl-28WBGene00020796IItranslationstructural component of ribosome (mitochondrial)yy
mrpl-4WBGene00020717Vtranslationstructural component of ribosome (mitochondrial)yy
nath-10WBGene00018866ItranslationrRNA modification (acetyltransferase)ynnd
nol-2WBGene00021073IItranslationrRNA modification (methyltransferase)ynnd
pie-1WBGene00004027IIItranscriptionrepressor of RNA polymerase IInndnd
pkc-3WBGene00004034IIsignaling/polaritynndnd
plk-1WBGene00004042IIIsignalingynnd
prp-31WBGene00022458ImRNA processingyy
rae-1WBGene00003803Itransportnuclear exportyn
rpl-2WBGene00004413Vtranslationstructural component of ribosomeyy
rpl-25.1WBGene00004438Xtranslationstructural component of ribosomeyy
rpoa-2WBGene00008781ItranslationrRNA synthesisynnd
rrbs-1WBGene00007617Vtranslationregulator of ribosome biogenesis (5S rRNA binding activity)yn
snr-3WBGene00004916IImRNA processingspliceosomal snRNP assemblyyy
spe-5WBGene00004959Itransportnndnd
sptl-3WBGene00011932Vmetabolismsphingolipid metabolismnndnd
T13H5.4WBGene00011758IImRNA processingsplicingyy
T26G10.1WBGene00012059IIItranslationrRNA modification (helicase)yy
tbb-1WBGene00006536IIIcytoskeletalyy
tln-1WBGene00006771Icytoskeletalbinds actin filamentsnndnd
W07E6.2WBGene00021074IItranslationribosome assembly (large subunit)ynnd
W09C5.1WBGene00012351Itranslationregulator of ribosome biogenesisyn
xpo-1WBGene00002078Vtransportnuclear exportnndnd
Y45F10D.7WBGene00012887IVotherRNA binding activityyn
ZK430.7WBGene00022742IIsignalingestrogen receptor binding activityyN