Table 2 Biallelic and/or parental-origin-dependent expression of genes in the genomic region between CALCR and ASB4 in mice and humans
Mouse chr6A1Human chr7q21.3
CALCRBi: all embryonic tissues (E12.5 and 14.5) (except brain)Sequencing[1]Bi: all fetal tissues (8-18 wk) (except brain)Sequencing[1]
M: embryonic brain (E15.5), adult brain (Brain-specific)RFLP[2]monoallelic: fetal brainns[1]
GNGT1Bi: embryonic tissues, placenta, yolk sac (E12.5 and 14.5)ns[1]Bi: all fetal tissues (8-18 wk), placentaSequencing[1]
TFPI2Bi: embryonic tissues (E12.5 and 14.5)Sequencing[1]absence of expression in fetus (8-18 wk)RT-PCR[1]
M: placenta, yolk sac (E12.5 and 14.5)Sequencing[1]M: placenta (polymorphic†††)Sequencing[1]
GNG11Bi: embryonic tissues, placenta, yolk sac (E12.5 and 14.5)ns[1]Bi: all fetal tissues (8-18 wk), placentaSequencing[1]
BET1Bi: embryonic tissues, placenta, yolk sac (E12.5 and 14.5)ns[1]Bi: all fetal tissues (8-18 wk), placentaSequencing[1]
COL1A2Bi: embryo (all tested tissues, E15.5)ns[3]Bi: all fetal tissues (8-18 wk), placentaSequencing[1]
CASD1Bi: embryo, placenta, yolk sac (E10 and 13)RFLP[4]Bi: all fetal tissues (8-18 wk), placentaSequencing[1]
Bi: neonate (brain)RFLP[4]
SGCEP: embryo at E13RFLP[5]P: patUPD7 cell line/ familyRT-PCR/ sequencing[7]
P: adult (brain, heart, kidney)RFLP[4]
PEG10P: embryo at E10Sequencing[4]P: embryonic villiRFLP[8]
P: patUPD7 cell lineRT-PCR[7]
P: fetus (8-18 wk), placentaSequencing[1]
PPP1R9ABi: embryo (brain, liver, lung, eye) (E15.5) & neonate (brain)Sequencing/ SNaPshot[6]Bi: all fetal tissues (8-18 wk) except muscleSequencing[1]
Mp: embryo (tongue), placenta, yolk sac & neonate (limb, tongue††)Sequencing/ SNaPshot[6]M: fetal muscle (8-18 wk), 1st trimester placentaSequencing[1]
PON1low expression in embryo, placenta, yolk sacns[4]undetectable (lymphoblasts)ns[9]
Bi: Neonate (liver, lung)RFLP[4]
PON3Mp: embryo (E10), placenta (E10) & yolk sac (E13)RFLP[4]Bi: all fetal tissues (8-18 wk), placentaSequencing[1]
Bi: Neonate (liver, lung)RFLP[4]
PON2Mp: placenta (E10) & yolk sac (E13)RFLP[4]Bi: all fetal tissues (8-18 wk), placentaSequencing[1]
Bi: Neonate (all tested tissues)RFLP[4]
ASB4M: embryo at E15.5 (All tested tissues)RFLP[3]Bi: fetus (8-18 wk) (liver, heart), placentaSequencing[1]
  • ns: data not shown, P: paternal expression, M: maternal expression, Mp: preferential maternal expression, Monoallelic: monoallelic expression (Parental origin was not determined due to absence of parental samples), E: embryonic day. Quantitative allele frequency measurement for SNPs. ††Limb & tongue represent skeletal muscle tissues, while placenta & yolk sac represent extra-embryonic tissues. †††Some placenta showed maternal expression and others showed biallelic expression. [1] Monk et al. 2008; [2] Hoshiya et al. 2003; [3] Mizuno et al. 2002; [4] Ono et al. 2003; [5] Piras et al. 2000; [6] Nakabayashi et al. 2004; [7] Grabowski et al. 2003; [8] Ono et al. 2001; [9] Okita et al. 2003.