Table 3 Perturbagens associated with at least three asthma-relevant asthma sample types. occurrence (connection to number of asthma tissues), associated asthma tissue/ sample type and their known association with allergy/ asthma/ lung diseases (known/ unknown) have been Mentioned
PerturbagenOccurrencesAssociated samplesIndicated in allergy/ asthma/ lung disease
KLF6 (Kruppel like factor 6)5AirEpi, Macrophages, FibroDistal, CD8+, NasalYes
BCL10 (B-cell lymphoma/ leukemia 10)4Macrophages, FibroDistal, CD4+, BloodYes
HOXB13 Homeobox protein Hox-B134Macrophages, Sputum, FibroDistal, NasalNo
IFNB1(Interferon beta 1)4Sputum, FibroDistal, CD8+, BloodYes
Entinostat4Macrophages, FibroDistal, CD8, NasalNo
ATOX1(Antioxidant 1 Copper Chaperone)3FibroDistal, CD4, FibroProximalNo
BAMBI(BMP and activin membrane bound inhibitor)3Macrophages, Sputum, BloodYes
BMS-3455413FibroDistal, CD8+, NasalYes
CCNL1 (cyclin L1)3Macrophages, FibroDistal, CD8+No
CDCA8 (cell division cycle associated 8)3AirEpi, CD8+, BloodNo
DHX8 (DEAH-box helicase 8)3Sputum, Bronchial, BloodYes
DTX2 (deltex E3 ubiquitin ligase)3AirEpi, Sputum, NasalNo
KLF3 (Kruppel like factor 3)3Bronchial, FibroDistal, CD8+Yes
LASP1 (LIM and SH3 protein 1)3AirEpi, Macrophages, CD8+Yes
LOXL1 (lysyl oxidase like 1)3AirEpi, Sputum, BloodYes
PPP2R3C (protein phosphatase 2 regulatory subunit B’’gamma)3AirEpi, Macrophages, BloodYes
PREB(prolactin regulatory element binding)3Macrophages, FibroDistal, FibroProximalNo
PUF60 (poly-U binding splicing factor 60)3Macrophages, CD8+, NasalNo
SORBS3 (sorbin and SH3 domain containing 3)3Macrophages, FibroProximal, NasalNo
TRIP10 (Thyroid Hormone Receptor Interactor 10)3Macrophages, Bronchial, FibroDistalNo
XPO7 (Exportin 7)3AirEpi, Sputum, BronchialYes
YWHAZ3AirEpi, Bronchial, NasalNo
Calyculin3Macrophages, FibroDistal, BloodNo