Table 2 Results from statistical analyses

Effect Type	Effect	Estimate (p-value)
		Open Field Phenotypes				VCM	Weight	EPS	Plasma
		Distance	Vertical	Centroid	Stereotypy	VCM	Weight	EPS	Plasma
Fixed Effects	Pre	−0.65^{^a}	−0.69^{^a}	−0.70^{^a}	−0.65^{^a}	–	−0.1181^{^a}	−0.7391^{^a}	–
	Sex	−112.74 (0.11)	−0.94 (0.91)	3.23 (0.44)	2.84 (0.73)	8.0108 ^{^b}	0.0092 (0.20)	0.8715 (0.29)	0.03297 (0.4329)
	Tmt	−911.69^{^a}	−165.80^{^a}	1.27 (0.80)	−13.34 (0.15)	18.4336^{^a}	0.0104 (0.03)	10.4421^{^a}	–
	Sex^*tmt	208.26 (0.23)	−3.18 (0.87)	−8.46 (0.48)	3.38 (0.87)	4.9340 (0.57)	−0.043^{^b}	−2.6416 (0.26)	–
Variance Components	Strain	300278^{^a}	7032.48^{^a}	1020.47^{^a}	2599.73^{^a}	611.53^{^a}	8.4e-4^{^a}	19.760^{^a}	0.04127^{^b}
	Strain^{^}Tmt*	86343^{^a}	3005^{^a}	114.54 (0.013)	451.66^{^b}	61.24^{^b}	2.9e-5 (0.51)	21.948^{^a}	–
	Strain^{^}Sex*	22771^{^b}	19910 (0.04)	3.72 (0.47)	199.56 (0.07)	3.57 (0.39)	2.1e-4^{^a}	0.00 (0.50)	0.01105^{^b}
	Strain^{^}Sex^{^}Tmt	4618 (0.26)	242 (1.0)	0.00 (0.50)	47.68 (0.31)	26.61 (0.06)	0.00 (1.0)	0.1648 (0.46)
Estimates	Fixed Tmt	50.50^{^a}	90.44^{^a}^{^a}	0.27 (0.76)	1.39 (0.25)	27.08^{^a}	5.358^{^b}	25.99^{^a}	–
	Fixed Sex	1.32 (0.27)	0.05 (0.96)	0.33 (0.72)	0.18 (0.84)	13.20^{^a}	5.37^{^b}	0.72 (0.4894)
	Random Tmt	46.09^{^a}	74.30^{^a}	4.91 (0.03)	8.347^{^b}	10.58^{^b}	0.29 (0.51)	40.82^{^a}	–
	Random Sex	6.78 (0.013)	3.15 (0.09)	0.006 (0.72)	2.368 (0.139)	2.45 (0.13)	9.95^{^b}	0.012 (0.71)
Overall Heritability		0.4	0.33	0.24	0.24	0.40	0.21	0.28	0.31
Treatment effect heritability		0.09	0.12	0.02	0.04	0.05	0.01	0.15	–

↵a P < 0.001.
↵b P < 0.01.