Table 3 ngn-1 transcriptome gene ontology (GO) term most significant hits by p-value. (A) GO-terms associated with down-regulated genes. (B) GO-terms associated with up-regulated genes. A. ngn-1 transcriptome Gene Ontology analysis: down-regulated genes (most significant p - value) B. ngn-1 transcriptome Gene Ontology analysis: up-regulated genes (most significant p - value)
Gene Ontology TermGO-term IDExpectedObservedEnrichment (FC)P-valueP-adj
iron bindingGO:00055060.658.43.3E-050.0042
tetrapyrrole bindingGO:00469060.7745.20.00110.069
RNA polymerase II regulatory region DNA bindingGO:00010120.7745.20.00110.069
transcription reg. region sequence-specific DNA bindingGO:00009760.8444.80.00170.069
organic acid metabolic processGO:00060822.273.10.0020.069
neurogenesisGO:00220081.453.70.00260.069
regulatory region nucleic acid bindingGO:0001067143.90.00390.07
double-stranded DNA bindingGO:00036901.143.70.00480.074
cellular developmental processGO:00488693.992.30.00620.086
immune system processGO:00023763.548142.1E-402.6E-38
response to biotic stimulusGO:00096072.833123.1E-261.9E-24
extracellular regionGO:00055768.2435.33.6E-191.5E-17
extracellular spaceGO:00056154.4306.93.1E-179.7E-16
metalloendopeptidase activityGO:00042221.5106.64.1E-071.0E-05
membraneGO:0016020971371.41.7E-050.00035
peptidase activityGO:00082336.7182.75.5E-050.00097
neuropeptide signaling pathwayGO:00072181.884.30.000110.0017
intrinsic component of membraneGO:0031224851181.40.000180.0026
cation bindingGO:004316924381.60.00220.027
incorrect protein topology responseGO:00359662.882.80.00230.027
zinc ion bindingGO:00082707.8162.10.00250.027
lytic vacuoleGO:00003231.453.50.00330.032
molting cycleGO:00423031.653.10.00620.055
structural constituent of cuticleGO:00423022.462.50.0110.091
protein catabolic processGO:00301634.91020.0110.091
collagen trimerGO:00055812.462.50.0120.091