Table 2 Candidate genes for the suppressors
Intragenic/ExtragenicSuppressor alleleCandidate geneChromosomeMutationRNAi of top-2(it7ts)a
smd-1 (control)0.8% (n = 8167)
Intragenicude6top-2IID809NNP
Extragenicude2tdpt-1IG328E
ude3tdpt-1IG219E
ude4tdpt-1IG117R
ude5tdpt-1IG270D91.9% (n = 2253)**
ude24tdpt-1IG270D
ude7tdpt-1IG270S
ude13tdpt-1IA355T
ude14mep-1IVG57D1.0% (n = 4624)ns
ude23nurf-1IIE1954K1.7% (n = 4253)ns
mep-1+nurf-19.2% (n = 3460)*
ude15top-3IIIP699S0.9% (n = 2102)ns
ude16viln-1IR552C1.0% (n = 1644)ns
nlp-38IG77R2.7% (n = 5680)ns
viln-1+nlp-386.9% (n = 8068)ns
  • a Percent of viable progeny from unc-4(e120) top-2(it7ts) hermaphrodites fed RNAi bacteria against the gene listed in column three at 24°C.

  • NP = not performed.

  • n = the number of embryos scored.

  • * P < 0.05, one-tailed student’s T-test.

  • ** P < 0.005, one-tailed student’s T-test.

  • ns indicates the data are not significant by the one-tailed student’s T-test.

  • ude = is the allele designation assigned to the Jaramillo-Lambert laboratory.