Table 1 Candidate paternal and maternal lifespan loci. For each locus, we list the lead genotyped variants, and for SRRM3 and APOE we also list the lead imputed variant, indicated with SNP ID prefix: bp. The additive effect of each allele at the candidate locus is given in years, scaled to the expected allelic dosage in the parental generation. h2snp is the fraction of variance in lifespan explained per snp. The statistical significance of the association at each candidate variant is given as an uncorrected (PUC) value and genomic control corrected (PGC) value. Significance of PGC after Bonferroni multiple test correction: *** PBonf < 0.001; * PBonf < 0.05; - PBonf > 0.05
LifespanLocusRSIDChrEffect AlleleEffect Allele Freq.1886 - 19181886 - 1940
Effect (years)SE (years)h2snp (%)PUCPGCEffect (years)SE (years)h2snp (%)PUCPGC
PaternalANRILrs13330429A0.490.650.090.0634.01e-133.21e-12***0.510.070.0397.00e-158.13e-13***
WAPLrs1088762310G0.10−0.840.150.0372.26e-087.89e-08*−0.510.110.0143.36e-061.92e-05
LPArs94579256A0.02−1.660.330.0305.49e-071.51e-06−1.710.250.0314.14e-121.83e-10***
SRRM3rs176857A0.280.380.100.0181.13e-042.08e-040.400.070.0195.41e-085.73e-07
bp757636247A0.320.420.070.0232.64e-094.39e-08*
CHRNA3/5rs93179415G0.35−0.340.090.0171.92e-043.40e-04−0.410.070.0233.19e-095.17e-08*
MaternalAPOErs442063819G0.18−0.600.130.0334.83e-066.60e-06−0.490.090.0225.94e-082.76e-07
bp4541194119C0.14−0.830.150.0481.86e-082.96e-08*−0.60.10.0262.53e-091.61e-08*