Table 3 AncestryDNA-UKB GWA meta-analysis of parental lifespan. The P value is given of the lead variant at each locus in the test of association with parental lifespan in the AncestryDNA, UKB and combined cohorts. The z-score transformed variant effect sizes and standard errors are listed for the AncestryDNA and UKB analyses. Variants which were significantly associated with lifespan in either the AncestryDNA or UKB cohorts, and were not significant in the meta-analysis, are provided at the bottom of the table
Meta-AnalysisAncestryDNAUKB
TraitLocusrsidchrbpPPEffect (z-score)SEPEffect (z-score)SE
PaternalCLESR2..PSRC1rs59983911098221664.43e-091.66e-030.0100.0034.00e-090.0150.003
LifespanMICA..MICBrs31316216314254998.86e-097.72e-04−0.0110.0033.60e-08−0.0120.002
LPArs14057088661610130131.13e-241.84e-13−0.0800.0111.10e-17−0.0770.009
LPLrs152858198246678.46e-102.44e-050.0120.0031.20e-070.0130.002
EPHX2..CLUrs78449658274420645.79e-109.06e-060.0130.0032.20e-070.0130.003
ANRILrs15565169221001761.57e-282.99e-150.0200.0031.30e-200.0200.002
ATXN2rs10774625121119102191.39e-089.97e-020.0040.0032.80e-120.0150.002
SEMA6Drs477449515476513624.92e-084.29e-03−0.0110.0043.30e-08−0.0190.003
CHRNA3/5rs978872115788028691.10e-318.49e-10−0.0160.0031.40e-32−0.0270.002
LDLRrs651172019112023062.73e-096.78e-050.0160.0041.70e-070.0180.003
APOErs76944919454100021.86e-204.31e-05−0.0160.0045.60e-24−0.0330.003
MaternalIP6K1rs98728643497920236.90e-105.61e-05−0.0110.0031.30e-07−0.0110.002
LifespanLPArs18669626561611117008.43e-093.33e-03−0.0340.0121.60e-08−0.0510.009
CHRNA3/5rs488707215789254351.92e-093.82e-050.0140.0036.80e-070.0130.003
APOErs42935819454119414.37e-572.53e-09−0.0230.0041.30e-68−0.0530.003
Not Replicated
PaternalSRMM3rs286890517757636243.41e-032.64e-090.0160.0032.60e-01−0.0030.002
LifespanWAPLrs1088762310883151813.32e-033.36e-06−0.0200.0049.20e-010.0000.004
ZW10rs17613838111136381771.92e-048.11e-010.0010.0036.10e-09−0.0160.003
C20orf187rs607799620109728392.28e-047.21e-010.0010.0034.60e-09−0.0130.002
Maternal LifespanPSORS1C3rs12651596311400476.43e-073.43e-01−0.0040.0043.60e-10−0.0160.003