Table 3 Haplotypes of the three NAT gene paralogs in the genus Pan
NAT1
Positiona79’63279’70379’85979’89779’92580’01480’07480’15380’31680’345
SNPbG76AC147TC303TT341CT369CC458TA518CT597GG760CA789G
Amino acid changeD26NI114TE173AI199ME254QI263M
Haplotypes
NAT1*1GCCTTCATGA
NAT1*2.T........
NAT1*3.........G
NAT1*4.T.....G..
NAT1*5A.........
NAT1*6....C.....
NAT1*7........C.
NAT1*8...C......
NAT1*9.....TC...
NAT1*10AT........
NAT1*11......C...
NAT1*12..T.......
NAT2
Positionc57’54957’58557’65857’70458’02758’09158’30258’44758’462
SNPbT36CA72CG145AG191AA514GC578TT789GA934GC949G
Amino acid changeL24FE49KR64QN172DT193M
Haplotypes
NAT2*1TAGGACTAC
NAT2*2.....T...
NAT2*3......G..
NAT2*4.......G.
NAT2*5........G
NAT2*6....G....
NAT2*7..A....G.
NAT2*8..AA...G.
NAT2*9.CA....G.
NAT2*10C...G....
NATP
Positionc28’14628’18928’23828’24228’27928’28528’30428’36828’40428’501
SNPb3174123127164170189253289386
Haplotypes
NATP*1GCAATTCCCT
NATP*2.......T..
NATP*3.......T..
NATP*4.......T..
NATP*5.......T..
NATP*6.......T.C
NATP*7..G....T..
NATP*8.......T.C
NATP*9.......T.C
NATP*10.......T.C
NATP*11.....A.T.C
NATP*12.....A.T.C
NATP*13.....A.TTC
NATP*14.....A.TTC
NATP*15.....A.TTC
NATP*16.T...A.T.C
NATP*17T....A.T.C
NATP*18...GCATT.C
NATP*19...GCATT.C
NATP (continued)
Positionc28’54328’56028’57528’57628’58228’61428’65928’66028’66128’748
SNPb428445460461467499544545546633
Haplotypes
NATP*1ACAGGTGCGT
NATP*2..........
NATP*3........A.
NATP*4....T.....
NATP*5.A........
NATP*6..........
NATP*7..........
NATP*8.....G....
NATP*9.....G....
NATP*10.....GA...
NATP*11..........
NATP*12..........
NATP*13.....G...C
NATP*14G.........
NATP*15G....G....
NATP*16.....G....
NATP*17..........
NATP*18..GA.G.T..
NATP*19..GA.GAT.
NATP (continued)
Positionc28’77128’95929’05729’103
SNPb656844942988
Haplotypes
NATP*1CTGA
NATP*2....
NATP*3....
NATP*4....
NATP*5....
NATP*6....
NATP*7....
NATP*8....
NATP*9T...
NATP*10T...
NATP*11....
NATP*12.C..
NATP*13T...
NATP*14T...
NATP*15T...
NATP*16T..T
NATP*17....
NATP*18..A.
NATP*19..A.
  • a Position (+18’000’000) on GRCh37/hg19.

  • b SNP position relative to the coding exon of NAT1, NAT2, or its paralog sequence on NATP (starts at position 1).

  • c Position (+18’200’000) on GRCh37/hg19.