Table 2 Models used for each analysis in this study

Model Number	Phenotype(s)	Unit	Variance Parameters
1	Pre^{^b}	Individuals	12^{^c}
2	Post^{^d}	Individuals	12^{^c}
3	delta^{^e}	Quartets	12^{^c}
4	delta^{^e}	Quartets	13^{^f}

↵a See study design in Figure 1 for overview of analyses. See Table 1 and Statistical Models and Methods for parameter and phenotype definitions.
↵b D0 [all].
↵c This count includes { }, { }, and
↵d D1pct, D2pct, D3pct, D4pct [mock] and D1pct, D2pct, D3pct, D4pct [flu].
↵e D1delta, D2delta, D3delta, and D4delta.
↵f This count includes and parameters in c.