| Genotype ATP1B2:c.130_131ins227 | wt/wt | wt/ins | ins/ins |
|---|---|---|---|
| Malinois cases (family 6 and MA133) | — | — | 5 |
| Malinois cases (families 1–5 and six isolated puppies)a | 13 | 1 | — |
| Malinois controls | 199 | 38 | — |
| Groenendael controls | 24 | 1 | — |
| Laekenois controls | 2 | — | — |
| Tervueren controls | 28 | 7 | — |
| Control dogs from other breedsb | 503 | — | — |
↵a Six of these Malinois puppies, which belonged to family 1–4, and one isolated case, MA152, were previously reported to be affected by SDCA1 caused by the KCNJ10:c.986T>C variant (Mauri et al. 2017).
↵b These dogs were specifically genotyped by fragment length analysis for the ATP1B2:c.130_131ins227 variant. The genome sequences of 146 independent control dogs were also homozygous wt/wt. Therefore, the number of control dogs totals 948.