Table 4 Deleterious and tolerated SNPs grouped according to Europe (EU)/Asia (AS) continent and domestic (DM)/wild (WB) status
ContinentPopulationSNP TypeaNonsignificant Genes of Nonsignificant PathwaysSignificant Genes of Nonsignificant PathwaysNonsignificant Genes of Significant PathwaysSignificant Genes of Significant PathwaysP-Valueb
AsiaASDMTolerated85341,1952,6251,1760.756
Deleterious6,8259542,144927
λASDM0.8000.7980.8170.788
ASWBTolerated6,2458432,0296360.033
Deleterious4,4325871,320391
λASWB0.7100.6960.6510.615
ASDM/ASWBλASDMASWB1.1271.1471.2551.282
EuropeEUDMTolerated5,1917161,6756200.023
Deleterious3,4294831,200349
λEUDM0.6610.6750.7160.563
EUWBTolerated2,6544168933460.001
Deleterious1,153198382103
λEUWB0.4340.4760.4280.298
EUDM/EUWBλEUDMEUWB1.5231.4181.6751.891
TotalTotalTolerated22,6243,1707,2222,7780.003
Deleterious15,8392,2225,0461,770
λTotal0.7000.7010.6990.637
  • SNP, single nucleotide polymorphism; ASDM, Asian domestic; ASWB, Asian wild boar; EUDM, European domestic; EUWB, European wild boar.

  • a λ corresponds to the ratio of deleterious vs. tolerated SNPs.

  • b P-value obtained from χ2 test of the 2 × 2 table containing nonoverlapping SNP sets (nonsignificant genes from nonsignificant pathways vs. significant genes from significant pathways).