Table 2 Power (% QTL identified) to validate QTL in the DGRP and DSPR for different sample sizes and true PVE by the simulated QTL
DGRPDSPR
BiallelicMultiallelicBiallelicMultiallelic
True PVESample SizeNaMappedbNaMappedbNaMapped (%)bNaMapped (%)b
51006000356 (5.9%)6000299 (5.0%)2000248 (12.4)2000273 (13.7)
51853000252 (8.4%)5000338 (6.7%)1000247 (24.7)1000251 (25.1)
101003000282 (9.4%)3000216 (7.2%)1000299 (29.9)1000310 (31.0)
101851000319 (31.9%)1000163 (16.3%)1000617 (61.7)1000631 (63.1)
201001000424 (42.4%)1000218 (21.8%)100069.5 (69.5)1000700 (70.0)
201851000940 (94.0%)1000638 (63.8%)1000972 (97.2)1000971 (97.1)
55001000781 (78.1)1000810 (81.0)
58781000984 (98.4)1000978 (97.8)
105001000992 (99.2)1000987 (98.7)
108781000997 (99.7)1000997 (99.7)
205001000998 (99.8)1000995 (99.5)
208781000999 (99.9)1000998 (99.8)
  • DGRP, Drosophila Genetic Reference Panel; DSRP, Drosophila Synthetic Population Resource; PVE, percentage of variance explained; QTL, quantitative trait loci.

  • a The number of simulations performed. Note that we simulated an increased number when power was low to generate enough mapped QTL to estimate the observed PVE accurately.

  • b The number simulations resulting in a significant, mapped QTL at the local region FWER threshold. The percentage (i.e., power) is in parentheses.