Table 1 Power (% QTL identified) and % validated in the DGRP and DSPR for different sample sizes and true PVE by the simulated QTL
DGRPDSPR
BiallelicMultiallelicBiallelicMultiallelic
True PVESample SizeNaMappedb% ValidatedcNaMappedb% ValidatedcNaMapped (%)b% ValidatedcNaMapped (%)b% Validatedc
5100600038 (0.6%)13.1%600035 (0.6%)2.9%200025 (1.3)16.0200024 (1.2)8.3
5185300049 (1.6%)4.1%500051 (1.0%)5.9%100069 (6.9)17.4100026 (4.6)45.6
10100300050 (1.6%)6.0%300038 (1.3%)5.3%100080 (8.0)33.7100062 (6.2)33.9
101851000149 (14.9%)31.0%100056 (5.6%)33.9%1000304 (30.4)73.01000309 (30.9)63.0
201001000216 (21.6%)46.0%100087 (8.7%)34.5%1000388 (38.8)74.01000373 (37.3)68.0
201851000852 (85.2%)93.0%1000456 (45.6%)75.0%1000876 (87.6)97.01000872 (87.2)98.0
55001000482 (48.2)90.01000539 (53.9)83.0
58781000928 (92.8)99.01000929 (92.9)97.0
105001000967 (96.7)1001000967 (96.7)99.0
108781000996 (99.6)1001000994 (99.4)100
205001000997 (99.7)1001000993 (99.3)100
208781000997 (99.7)1001000996 (99.6)100
  • DGRP, Drosophila Genetic Reference Panel; DSRP, Drosophila Synthetic Population Resource; PVE, percentage of variance explained; QTL, quantitative trait loci.

  • a The number of simulations performed. Note that we simulated an increased number when power was low to generate enough mapped QTL to estimate the observed PVE accurately.

  • b The number of simulations resulting in a significant, mapped QTL. The percentage (i.e., power) is in parentheses.

  • c The percentage of the mapped QTL that were identified in a second set of simulated QTL within the population (see Methods for details).