Table 3 Rat Mcs3-nominated human genes and amplified region correlated with breast cancer development
IDNameLocusRefSeq on FunctionReference
Genes
 ILKIntegrin-linked kinase11p15.4Serine/threonine kinase that regulates integrin-mediated signalingYang et al. (2013)
 IL18BPInterleukin 18 binding protein11q13.4Inhibitor of proinflammatory cytokine IL18Yang et al. (2015)
 EMSYEMSY, BRCA2 interacting transcriptional repressor11q13.5Repression of BRCA2-mediated DNA repairHughes-Davies et al. (2003), Madjd et al. (2014)
 PAK1p21 (RAC1) activated kinase 111q13.5q14.1Serine/threonine kinase that regulates cell motility and morphologyAdam et al. (2000), Wang et al. (2005), Bostner et al. (2007)
 RSF1Remodeling and spacing factor 111q14.1Histone chaperone involved in RSF chromatin-remodeling complexRen et al. (2014)
 GAB2GRB2 associated binding protein 211q14.1Adapter protein involved in signal transduction with a known role in PI3K activationBocanegra et al. (2010)
 CYP2C19Cytochrome P450 family 2 subfamily C member 1910q23.33Monooxygenase involved in xenobiotic and estrogen metabolismJustenhoven et al. (2009), Sangrajrang et al. (2009), Gan et al. (2011)
Amplified region
 11q13/14Amplified in a subset of breast cancers that are typically ER+ and have a poor prognosisTsuda et al. (1989)