Table 1 Common genomic variation in 10 methotrexate-resistant strains
GroupSample IDGenomic Variants
A2; 3; 5; 6; 9sec21(S96L); ρ0
B4; 7; 8sec21(S96L); ρ0; vas1(F227V)
C1; 10sec21(S96L); ρ0; dit1(A39T); fkh1(A443D); rkm1(Y418N)
  • Genomic variants shared between resistant strains are binned into groups A, B, and C. Unlike the parent BY4741 strain, all mutant strains are ρ0, lacking mitochondrial genome.