Table 1 Joint probabilities for simulating genotypes of sibling pairs
Genotype of Sibling 1p(Sibling 2 = 0)p(Sibling 2 = 1)p(Sibling 2 = 2)
0q2(q + p2/4)pq2(1 − p/2)(pq/2)2
1pq2(1 − p/2)pq(1 + pq)p2q(1 − q/2)
2(pq/2)2p2q(1 − q/2)p2(p + q2/4)
  • Frequency of the minor allele is set by the parameter p, then q = 1 − p.