Table 3 Association tests of CD55 SNPs (MAF > 1%) with severe malaria phenotypes
Severe Malaria (Ncases = 831, Ncontrols = 903)Severe Malaria Anemia (Ncases = 507, Ncontrols = 903)Cerebral Malaria (Ncases = 165, Ncontrols = 903)Parasite Density (Log) (Ncases = 767)
No.SNP IDMaj/Min AlleleMAF (Aff/Unaff)OR (95% C.I.)p-ValueOR (95% C.I.)p-ValueOR (95% C.I.)p-Valueβ (SE)p-Value
1rs6685886C/A0.27/0.231.12 (0.95–1.31)0.1811.15 (0.95–1.39)0.1441.01 (0.83–1.44)0.525−0.09 (0.12)0.476
2rs28371586C/G0.02/0.030.84 (0.54–1.32)0.4570.73 (0.41–1.20)0.2291.21 (0.61–2.40)0.5870.54 (0.37)0.147
3rs7542430C/G0.01/0.020.44 (0.25–0.79)0.0060.40 (0.20–0.81)0.0110.84 (0.36–1.97)0.681−0.69 (0.48)0.158
4rs28371588G/T0.04/0.040.88 (0.61–1.25)0.4690.83 (0.54–1.28)0.3931.07 (0.59–1.94)0.8290.03 (0.30)0.910
5rs2564979T/A0.03/0.040.82 (0.55–1.21)0.3120.85 (0.55–1.33)0.4880.57 (0.25–1.29)0.1760.11 (0.32)0.740
6rs116473488G/A0.02/0.020.86 (0.52–1.41)0.5560.86 (0.48–1.53)0.5990.56 (0.20–1.60)0.2780.02 (0.42)0.967
7rs28371628G/A0.08/0.071.24 (0.93–1.64)0.1411.14 (0.82–1.59)0.4361.33 (0.84–2.01)0.228−0.04 (0.22)0.849
  • Severe malaria, severe malaria anemia, cerebral malaria, and parasite density results of logistic regression analyses (linear regression for parasite density) are presented, assuming an additive mode of inheritance adjusted for gender, age, and ethnicity. No., number; SNP ID, single nucleotide polymorphism identifier; Maj, major; Min, minor; MAF, minor allele frequency; Aff, affected individuals; Unaff, unaffected individuals; OR, odds ratio.