Severe Malaria N_{cases} = 831, N_{controls} = 903 | Severe Malaria Anemia N_{cases} = 522, N_{controls} = 903 | Cerebral Malaria N_{cases} = 203, N_{controls} = 903 | Parasite Density (Log) N_{cases} = 767 | |||||||
---|---|---|---|---|---|---|---|---|---|---|

Haplotype | 1-2-3-4-5-6-7^{a} | Frequency (Aff/Unaff) | p-Value^{b} | Simulated p-Value^{c} | p-Value^{b} | Simulated p-Value^{c} | p-Value^{b} | Simulated p-Value^{c} | p-Value^{b} | Simulated p-Value^{c} |

CD55-1 | CCCGTGG | 0.55/0.57 | 0.475 | 0.487 | 0.673 | 0.665 | 0.325 | 0.342 | 0.428 | 0.423 |

CD55-2 | ACCGTGG | 0.25/0.21 | 0.031 | 0.036 | 0.027 | 0.024 | 0.100 | 0.108 | 0.298 | 0.265 |

CD55-3 | CCCGTGA | 0.08/0.07 | 0.133 | 0.116 | 0.509 | 0.507 | 0.112 | 0.111 | 0.820 | 0.821 |

CD55-4 | CCCTTGG | 0.04/0.04 | 0.403 | 0.414 | 0.361 | 0.347 | 0.951 | 0.941 | 0.689 | 0.729 |

CD55-5 | CCCGAGG | 0.03/0.03 | 0.255 | 0.265 | 0.368 | 0.346 | 0.087 | 0.084 | 0.796 | 0.802 |

CD55-6 | CGCGTGG | 0.02/0.03 | 0.484 | 0.489 | 0.372 | 0.375 | 0.969 | 0.968 | 0.629 | 0.630 |

CD55-7 | CCCGTAG | 0.02/0.02 | 0.524 | 0.534 | 0.630 | 0.639 | 0.232 | 0.255 | 0.894 | 0.889 |

CD55-8 | ACGGTGG | 0.01/0.02 | 0.011 | 0.007 | 0.024 | 0.031 | 0.659 | 0.646 | 0.124 | 0.120 |

Aff, affected individuals; Unaff, unaffected individuals; SNP, single nucleotide polymorphism.

↵a Refers to SNP number as designated in Table 2.

↵b Results of haplotypic-specific score tests adjusted for gender, age, and ethnicity assuming an additive mode of inheritance.

↵c Simulation p-values are computed based on a permuted reordering of the trait and covariates in HaploStats (Schaid

*et al.*2002).