Table 4 Association tests of CD55 haplotypes of ≥ 1% frequencies with severe malaria
Severe Malaria Ncases = 831, Ncontrols = 903Severe Malaria Anemia Ncases = 522, Ncontrols = 903Cerebral Malaria Ncases = 203, Ncontrols = 903Parasite Density (Log) Ncases = 767
Haplotype1-2-3-4-5-6-7aFrequency (Aff/Unaff)p-ValuebSimulated p-Valuecp-ValuebSimulated p-Valuecp-ValuebSimulated p-Valuecp-ValuebSimulated p-Valuec
CD55-1CCCGTGG0.55/0.570.4750.4870.6730.6650.3250.3420.4280.423
CD55-2ACCGTGG0.25/0.210.0310.0360.0270.0240.1000.1080.2980.265
CD55-3CCCGTGA0.08/0.070.1330.1160.5090.5070.1120.1110.8200.821
CD55-4CCCTTGG0.04/0.040.4030.4140.3610.3470.9510.9410.6890.729
CD55-5CCCGAGG0.03/0.030.2550.2650.3680.3460.0870.0840.7960.802
CD55-6CGCGTGG0.02/0.030.4840.4890.3720.3750.9690.9680.6290.630
CD55-7CCCGTAG0.02/0.020.5240.5340.6300.6390.2320.2550.8940.889
CD55-8ACGGTGG0.01/0.020.0110.0070.0240.0310.6590.6460.1240.120
  • Aff, affected individuals; Unaff, unaffected individuals; SNP, single nucleotide polymorphism.

  • a Refers to SNP number as designated in Table 2.

  • b Results of haplotypic-specific score tests adjusted for gender, age, and ethnicity assuming an additive mode of inheritance.

  • c Simulation p-values are computed based on a permuted reordering of the trait and covariates in HaploStats (Schaid et al. 2002).