Table 5 CD55 rare variant analyses including eight SNPs with MAF ≤ 1%
Severe MalariaSevere Malaria AnemiaCerebral MalariaHyperparasitemia (> 200,000/µl)
Ncases = 831, Ncontrols = 903Ncases = 507, Ncontrols = 903Ncases = 165, Ncontrols = 903Ncases = 220, Ncontrols = 547
p-Valuep-Valuep-Valuep-Value
Univariate tests
 CMC0.9520.9790.8900.507
 WSS0.9540.9760.8350.451
 C(α)0.4000.4120.7770.641
Multivariate testsa
 CMC0.9350.9630.9040.423
 WSS0.9720.9700.9070.491
 VT test (13 variants)0.9660.9820.8290.896
  • CMC, combined and multivariate collapsing; WSS, weighted sum statistic; VT, variable-thresholds methods.

  • a Adjusted for age, gender, and ethnic group.