Table 3 Modifier genes and their properties
GeneSymbolLocationAlleleΣPcd5-9 Mean ± SD (N)MI ΣPcd5-9m/+/ΣPcd5-9WT# Cells Mean ± SD (N)Human Orthologs
Control0.35 ± 0.15 (88)1251 ± 5 (44)No
teashirttsh2L:21,828,593..21,837,01180.08 ± 0.08 (20)0.22281 ± 11 (20)TSHZ3
2757R80.16 ± 0.08 (21)0.46269 ± 6 (21)
scrawnyscny3L:5,769,002..5,776,271203310.04 ± 0.06 (19)0.11227 ± 5 (19)USP3
TRiP. HMS020440.12 ± 0.06 (21)0.36260 ± 5 (21)
aurora borealisbora3L:18,622,692..18,624,751EY217510.15 ± 0.14 (15)0.42225 ± 8 (15)BORA
Trithorax-likeTrl3L:14,747,929..14,761,049s23250.14 ± 0.10 (24)0.41196 ± 8 (24)NACC1
MI027410.14 ± 0.15 (19)0.40233 ± 4 (19)
Mutagen sensitive 312mus3123L:7,329,132..7,333,471D10.07 ± 0.11 (16)0.19218 ± 7 (16)SLX4
TRiP. HMS001920.11 ± 0.06 (16)0.31220 ± 7 (16)
Cell division cycle 27Cdc273L:7,245,481..7,249,340L71230.13 ± 0.10 (15)0.38324 ± 7 (15)CDC27
TRiP. HM040240.12 ± 0.13 (21)0.36215 ± 6 (21)
Six4Six43L:20,788,886..20,792,777EY098330.18 ± 0.08 (19)0.52254 ± 8 (19)SIX4
TRiP. HM052540.18 ± 0.15 (17)0.50245 ± 10 (17)
mushroom body-expressedmub3L:21,844,788..21,932,702MI105750.13 ± 0.16 (16)0.38217 ± 7 (16)PCBP1-3
TRiP. HMS001890.13 ± 0.08 (16)0.37220 ± 6 (16)
  • The name, location, allele, and modifier properties of one or two alleles of the eight suppressor of variegation genes are summarized. ΣPcd5-9 = the sum of the change probabilities during DIV5–9 [mean ± SD (N = number of follicles scored)]. MI = ΣPcd5-9m/+/ΣPcd5-9WT. All ΣPcd5-9 values (and hence MI values) differed significantly between modifier alleles and control (P < 0.001). #Cells = the number [mean ± SD (N = number of follicles scored)] of follicle cells on the visible surface of a mounted stage 10 follicle. Values shown in italics (decrease) or bold (increase) differ significantly from control (P < 0.01, Student’s t-test). MI, modification index; TRiP, transgenic RNAi Project.