Table 2 KEGG pathways underlying eQTL biological effects in the white adipose tissue transcriptome in the GK × BN F2 cross
Congenics
RankKEGG IDP ValueCountSizeTermUpregulationDownregulation
15332<0.011734Graft vs. host disease
24145<0.0141128Phagosome
34940<0.011839Type 1 diabetes mellitus
45416<0.012461Viral myocarditisGK.BN7a, 8a, 10_7a
54612<0.012258Antigen processing and presentationBN.GK7aBN.GK1p; GK.BN10_7a
65330<0.011637Allograft rejection
75320<0.011639Autoimmune thyroid disease
84514<0.012992Cell adhesion moleculesBN.GK1v,10a; GK.BN8a, 10_7a
91100<0.01167798Metabolic pathways
105140<0.011953LeishmaniasisBN.GK7a, 7dGK.BN10_7a
115322<0.011959Systemic lupus erythematosus
12380<0.011127Tryptophan metabolism
1351500.011233Staphylococcus aureus infection
142500.01922Alanine, aspartate, and glutamate metabolism
152800.011234Valine, leucine, and isoleucine degradationBN.GK5a; GK.BN7a, 8a, 10_7aBN.GK7d
163600.0159Phenylalanine metabolism
173500.01716Tyrosine metabolism
186500.02717Butanoate metabolism
19710.021133Fatty acid metabolismGK.BN7a, 8a
207900.0247Folate biosynthesis
2151440.021134Malaria
225110.02614Other glycan degradation
2346500.021970Natural killer cell-mediated cytotoxicityBN.GK7a, 8bGK.BN7a, 8a, 10_7a
2446400.021552Hematopoietic cell lineageGK.BN10_7a
259820.031344Drug metabolism – cytochrome P450GK.BN7a, 8a, 10_7a
262700.03927Cysteine and methionine metabolismBN.GK1v; GK.BN7a
2749750.03927Fat digestion and absorption
284500.04512Selenocompound metabolism
2949700.051557Salivary secretion
3045120.051557Extra-cellular matrix-receptor interactionBN.GK1b, 1q, 1v, 5c, 10a; GK.BN8a, 10_7a
  • Data were analyzed with sex and cross as additive covariates. Congenic strains showing upregulation or downregulation in pathways identified in F2 hybrids are listed. Details of pathways can be found at www.genome.jp/kegg/.