Table 4 Association of TMEM252 rs35179438 with human macrophage expression of 28 OXPHOS genes
GeneProbesChrProbe_StartProbe_EndβaSEMP Value
M19 OXPHOS genes
 SDHBILMN_1667257117,476,54117,476,590−0.0530.00942.66 × 10−8
 NDUFB3ILMN_21199452201,943,702201,944,702−0.0340.01205.24 × 10−3
 COX17ILMN_21877183119,396,160119,396,209−0.0310.01390.0286
 ATP5IILMN_17725064678,058678,107−0.0200.00900.0244
 UQCRQILMN_16664715132,174,747132,174,796−0.0450.01083.55 × 10−5
 COX7A2ILMN_1701293675,950,94375,950,943−0.0280.01047.53 × 10−3
 ATP5J2ILMN_2307883799,217,92999,217,978−0.0350.01121.58 × 10−3
 NDUFB2ILMN_21173307140,402,713140,402,762−0.0390.01221.44 × 10−3
 COX6CILMN_16541518100,904,152100,904,201−0.0240.00834.07 × 10−3
 COX8AILMN_18094951163,742,26363,743,263−0.0420.01081.16 × 10−4
 NDUFA9ILMN_1760741124,796,1514,796,200−0.0490.01241.04 × 10−4
 ATP5G2ILMN_16605771254,063,07154,063,120−0.0060.01330.675
 COX6A1ILMN_178363612120,876,242120,876,291−0.0180.01180.119
 NDUFA11ILMN_2175712195,945,9525,946,001−0.0280.01150.0142
 NDUFB7ILMN_18136041914,816,06814,817,068−0.0200.01140.0764
 COX6B1ILMN_21546711936,139,23236,139,281−0.0280.00940.0355
 ATP5JILMN_23480932128,180,16828,180,217−0.0410.01091.63 × 10−4
 NDUFA1ILMN_1784286X119,005,887119,005,936−0.0340.00996.42 × 10−4
M15 OXPHOS genes
 ATP5F1ILMN_17219891112,003,559112,003,608−0.0220.00930.0195
 PPA2ILMN_16877854106,292,029106,293,029−0.0230.01480.123
 NDUFC1ILMN_17336034140,216,254140,217,2540.0070.01260.559
 NDUFA4ILMN_1751258711,006,66811,006,717−0.0070.01230.559
 ATP5C1ILMN_1701269107,801,0697,801,118−0.0320.01330.0157
 SDHDILMN_169848711111,966,144111,966,193−0.0160.01450.262
 ATP5LILMN_207928511118,280,301118,280,350−0.0130.01600.426
 NDUFAB1ILMN_21790181623,684,93423,684,983−0.0260.01380.0561
 ATP5HILMN_16663721775,524,60775,524,656−0.0340.00975.44 × 10−4
 NDUFV2ILMN_2086417189,126,8719,127,871−0.0220.01250.0754
  • a Effect of the minor rs35179438 TA allele on gene expression. Its allele frequency was 0.25 and its r2 imputation quality was 0.79.