Table 2 Enrichment analysis on the most preserved human modules
Preserved ModulePathwayEnrichment ScoreFDRNo. of GenesGenes
M19 (nc = 131)Oxidative phosphorylation8.923.28 × 10−1118NDUFB3, ATP5J2, COX7A2, NDUFB7, NDUFA9, COX8A, ATP5G2, UQCRQ, NDUFA1, COX6C, NDUFB2, NDUFA11, SDHB, COX6B1, COX6A1, ATP5I, COX17, ATP5J
 Huntington disease8.85 × 10−817NDUFB3, CLTA, COX7A2, POLR2L, NDUFB7, NDUFA9, COX8A, POLR2I, ATP5G2, UQCRQ, NDUFA1, COX6C, NDUFB2, SDHB, COX6B1, COX6A1, ATP5J
 Diabetes pathway3.62 × 10−720NDUFB3, ATP5J2, NDUFB11, NDUFB7, NDUFA9, COX8A, NDUFA13, UQCRQ, NDUFA1, NDUFA12, COX6C, NDUFB2, NDUFA11, SDHB, IDH3G, COX6B1, DAD1, COX6A1, ATP5I, ATP5J
 Parkinson disease1.31 × 10−614NDUFB3, COX7A2, NDUFB7, NDUFA9, COX8A, ATP5G2, NDUFA1, UQCRQ, NDUFB2, COX6C, SDHB, COX6B1, COX6A1, ATP5J
 Alzheimer disease2.57 × 10−514NDUFB3, COX7A2, NDUFB7, NDUFA9, COX8A, ATP5G2, NDUFA1, UQCRQ, NDUFB2, COX6C, SDHB, COX6B1, COX6A1, ATP5J
M15 (nc = 137)Oxidative phosphorylation4.170.00310NDUFA4, NDUFV2, SDHD, NDUFAB1, ATP5F1, ATP5C1, ATP5L, NDUFC1, ATP5H, PPA2
 Parkinson disease0.0259NDUFA4, CASP9, NDUFV2, SDHD, NDUFAB1, ATP5F1, ATP5C1, NDUFC1, ATP5H
 Huntington disease0.04410NDUFA4, CASP9, NDUFV2, SDHD, NDUFAB1, ATP5F1, ATP5C1, NDUFC1, ATP5H, TBPL1
 Alzheimer disease0.149NDUFA4, CASP9, NDUFV2, SDHD, NDUFAB1, ATP5F1, ATP5C1, NDUFC1, ATP5H
 Diabetes pathway0.3013NDUFA4, SEC11C, NDUFAB1, ATP5F1, NDUFC1, DLD, SDHD, NDUFV2, ATP5C1, ATP5L, ATP5H, SRP9, FH
 Proteasome3.721.37 × 10−38UBE2N, PSMD14, UBE2D2, PSMD12, PSMC2, UCHL5, PSMD6, PSMD7
M21 (nc = 96)Ribosome26.708.85 × 10−2722RPL18, RPSA, RPL17, RPL35, RPS9, RPL27, RPL38, RPS6, RPS5, RPS25, RPS19, RPL31, RPL22, RPL3, RPL5, RPS10, RPL11, RPL4, RPS20, RPL10A, UBA52, RPS24
  • Modules M17, M23, and M22 were not significantly enriched for any specific biological pathways. FDR, false discovery rate; nc, number of consistent genes in the module.