Table 2 Genes whose disruption confers sensitivity to 100 ng/ml caspofungin in YPD medium
C gla Locus TagS. cerevisiae HomologGene NameDescription of Gene Product (Engel et al. 2016)
PKC/cell wall integrity pathway
CAGL0I06512g YER155cBEM2RhoGAP involved in the control of cytoskeleton organization
CAGL0C05599g YDL240wLRG1Putative GAP appears to specifically regulate β-1,3 glucan synthesis
CAGL0J03828g YPL140CMKK1MAPKK involved in control of cell integrity
CAGL0G09559g YOR188wMSB1Unknown function; may be involved in positive regulation of β-1,3 glucan synthesis and the Pkc1-MAPK pathway
CAGL0G01320g YNL053WMSG5Dual-specificity protein phosphatase/ regulates Slt2
CAGL0E04620g YDR055wPST1Cell wall protein that contains a putative GPI-attachment site
CAGL0J00539g YHR030cSLT2Serine/threonine MAP kinase; regulates cell wall integrity
CAGL0A04565g YER111cSWI4DNA binding component of the SBF complex
Cytoskeleton and vesicular transport
CAGL0J04312g YBL017CPEP1Type I transmembrane sorting receptor for multiple vacuolar hydrolases
CAGL0E05302g YOR329cSCD5Protein required for normal actin organization and endocytosis
CAGL0G05786g YDL212wSHR3Endoplasmic reticulum packaging chaperone
CAGL0K05291g YPR032WSRO7Effector of Rab GTP-binding protein Sec4
High affinity Ca2+ influx (HACS)
CAGL0B02211g YGR217WCCH1Voltage-gated high-affinity Ca2+ channel
CAGL0M00748g YLR443WECM7Role in Ca2+ uptake
CAGL0M03597g YNL291CMID1Ca2+-permeable cation channel required for Ca2+ influx
Mannan synthesis
CAGL0K11231g YDR245wMNN10Subunit of a Golgi mannosyltransferase complex
CAGL0M02871g YJL186wMNN5α-1,2-mannosyltransferase
CAGL0J08734g YAL023cPMT2Protein O-mannosyltransferase
CAGL0B02321g YML115CVAN1Component of the mannan polymerase I
Cell signaling/response to stress
CAGL0L11110g YLR433cCNA1Calcineurin A; regulates Crz1
CAGL0K01507g YDL035cGPR1Plasma membrane GPCR; nutritional state sensor
Vacuole
CAGL0F06347g YMR054WSTV1Subunit a of the vacuolar-ATPase V0 domain
Transcriptional/translational regulation
CAGL0M06831g YNL027wCRZ1TF, activates transcription of stress response genes
CAGL0J10120g YNL068cFKH2Forkhead family transcription factor
CAGL0M13431g YHR187wIKI1Subunit of hexameric RecA-like ATPase Elp456 elongator subcomplex
CAGL0C04477g YDL005cMED2Subunit of the RNA polymerase II mediator complex
CAGL0M07029g YCR077CPAT1Deadenylation-dependent mRNA-decapping factor
CAGL0J03322g YER082CUTP7Nucleolar protein/processing of pre-18S rRNA
CAGL0H04367g YML076CWAR1Homodimeric Zn2Cys6 zinc finger transcription factor
DNA replication/repair/cell cycle regulation
CAGL0D06028g YJR053wBFA1Component of the GTPase-activating Bfa1-Bub2 complex
CAGL0I02222g YHR164CDNA2Tripartite DNA replication factor
CAGL0K09438g YOR144cELG1Subunit of a complex important for DNA replication/genome integrity
CAGL0A03300g YGL192wIME4mRNA N6-adenosine methyltransferase required for entry into meiosis
CAGL0D05786g YLL002wRTT109Histone acetyltransferase
CAGL0A03432g YLR032wRAD5DNA helicase
CAGL0E02475g YOL004WSIN3Component of the Sin3-Rpd3 histone deacetylase complex
Proteosome
CAGL0G09493g YOR191wULS1Protein involved in proteolytic control of sumoylated substrates
Miscellaneous and unknown functions
CAGL0E03355g YLL015WBPT1ABC type transmembrane transporter of MRP/CFTR family
CAGL0J08910g YLR213cCRR1Putative glycoside hydrolase of the spore wall envelope
CAGL0M05511g YBR207wFTH1Putative high affinity iron transporter
CAGL0E03311g YGR163wGTR2Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle
CAGL0I07447g YOL103wITR2Myo-inositol transporter
CAGL0J07436g YNL231cPDR16PITP controlled by the multiple drug resistance regulator Pdr1
CAGL0H04213g YML081WTDA1Protein kinase with unknown role; localizes to cytosol and nucleus
CAGL0J09966g YNL064cYDJ1Type I HSP40 cochaperone
CAGL0M08250g YKL175wZRT3Vacuolar membrane zinc transporter
CAGL0L05060g YKL075cUnknown function; localizes to cytosol
CAGL0K03377g YMR102CUnknown function; paralog of Dgr2