Table 2 DSX targets with consistent DSX regulation across strains
GeneChr.Sex BiasRegulatory ModeDSX OccupancyaDSX Occupancyb
Cpr72Ea3LFemaleFemale specific activator00
Mp202RFemaleFemale specific activator01
CG315223RFemaleFemale specific activator10
trpl2RFemaleMale specific repressor00
CG37592LFemaleMale specific repressor10
Yp2XFemaleMale specific repressor11
Fmo-22RFemaleMale specific repressor11
Yp3XFemaleOpposing effects01
Yp1XFemaleOpposing effects11
rost2LFemaleOpposing effects/11
Male specific repressor
CG150123LMaleFemale specific repressor00
mav4MaleFemale specific repressor00
CG121582RMaleFemale specific repressor00
Cyp4d212LMaleFemale specific repressor00
CG311453RMaleFemale specific repressor10
CG185473RMaleFemale specific repressor10
Cyp313a13RMaleOpposing effects00
  • Genes with patterns of sex-differential expression in wild-type, dsxD pseudo male, and dsx null comparisons, and the same regulatory mode in both Canton S and Berlin strains (FDR < 0.10). Sex bias, the direction of sex-differential expression: Female (Female-biased) or Male (Male-biased); Regulatory mode, the seven types of DSX regulation; DSX occupancy.

  • a DSXM and DSXF ChIP-seq in S2 cells and DSXM and DSXF Dam-ID in female ovaries, and male and female fat body (Clough et al. 2014; Table S1).

  • b DSXF Dam-ID in adult females (Luo et al. 2011; Table S1). Bold indicates validated DSX targets.