Table 3 Most frequently amplified and deleted regions in glioblastoma samples
EventNRegionGenes
Amplification24q11-q12DCUN1D4, LRRC66, SGCB, SPATA18, SCFD2, FIP1L1, LNX1, CHIC2, GSX2, PDGFRA, KIT, KDR, SRD5A3, TMEM165, CLOCK, PDCL2
Amplification147p12.2-p11.2VWC2, ZPBP, IKZF1, FIGNL1, DDC, GRB10, COBL, POM121L12, VSTM2A, SEC61G, EGFR, LANCL2, SEPT14, ZNF713, GBAS, PSPH, CCT6A, SUMF2, PHKG1, CHCHD2
Amplification27q31.2CAV2, CAV1, MET, CAPZA2
Amplification412q13.2-q13.3NEUROD4, OR9K2, OR10A7, OR6C74, OR6C6, OR6C1, OR6C3, OR6C75, OR6C65, PHC1B, OR6C76, OR6C2, OR6C70, OR6C68, OR6C4, OR2AP1, OR10P1, METTL7B, ITGA7, BLOC1S1, RDH5, CD63, GDF11, SARNP, ORMDL2, DNAJC14, MMP19, WIBG, DGKA, SILV, CDK2, RAB5B, SUOX, IKZF4, RPS26, ERBB3, PA2G4, ZC3H10, FAM62A, MYL6, SMARCC2, RNF41, OBFC2B, SLC39A5, ANKRD52, COQ10A, CS, CNPY2, PAN2, IL23A, STAT2, APOF, TIMELESS, MIP, SPRYD4, GLS2, RBMS2, BAZ2A, ATP5B, PTGES3, NACA, PRIM1
Amplification312q14.3-q15CAND1, DYRK2
Deletion21p32.3DMRTA2, FAF1
Deletion209p22.1-p21.3SLC24A2, MLLT3, KIAA1797, PTPLAD2, IFNB1, IFNW1, IFNA21, IFNA4, IFNA7, IFNA10, IFNA16, IFNA17, IFNA14, IFNA5, KLHL9, IFNA6, IFNA13, IFNA2, IFNA8, IFNA1, MTAP, C9orf53, CDKN2A, CDKN2B, DMRTA1, ELAVL2, C9orf134
Deletion210q23.2-q23.31PAPSS2, ATAD1, PTEN
  • The genes of potential importance are shown in bold. N, number of GBM cases.