Table 1 Whole transcriptome mRNA editing screening studies in vertebrates

Study	Species	Cells	Edited Sites (N)	Matched DNA^{^a}	Replicates^{^b}	Potential Biases
(Ju et al. 2011)	H. sapiens	Immortalized B cells	1809	Yes	2/17	Splice, homopolymer, strand, extremity
(Li et al. 2011)	H. sapiens	Immortalized B cells	28,766	Yes	2/27	Splice, homopolymer, multimapping, strand, extremity
(Bahn et al. 2011)	H. sapiens	Glioblastoma cells	10,000	No	2/2	Splice, homopolymer, multimapping, strand, extremity
(Peng et al. 2012)	H. sapiens	Immortalized B cells	22,688	Yes	1/1	Splice, homopolymer, extremity
(Park et al. 2012)	H. sapiens	14 ENCODE cell lines	5695	No	1/1	Homopolymer, extremity, multimapping
(Kleinman et al. 2012)	H. sapiens	Immortalized B cells	1503	Yes	1/2	Homopolymer
(Ramaswami et al. 2012)	H. sapiens	ENCODE cell lines	150,865	No	1/2	Strand, multimapping
(Picardi et al. 2012)	H. sapiens	Spinal cord cells	15	Yes (Exome)	1/1	Homopolymer, multimapping, strand
(Bazak et al. 2014)	H. sapiens	16 tissues	1,586,270	No	1/1	Homopolymer, multimapping, strand
(Chen 2013)	H. sapiens	7 ENCODE cell lines	259,385	No	1/2	Multimapping
(Chan et al. 2014)	H. sapiens	Liver cells	20,007	No	1/3	Splice, homopolymer, multimapping, strand, extremity
(Mo et al. 2014)	H. sapiens	Prostate cancer cells	16,194	Yes	2/10	Homopolymer, multimapping, strand, extremity
(Sakurai et al. 2014)	H. sapiens	Brain cells	19,791	No	1/1	Splice, homopolymer, multimapping, strand, extremity
(Toung et al. 2014)	H. sapiens	Immortalized B cells	5997	No	2/2	Multimapping, strand, extremity
(Zhang and Xiao 2015)	H. sapiens	Immortalized B cells	22,715	No	1/1	Multimapping, extremity
(Hu et al. 2015)	H. sapiens	Hepatocellular carcinoma cells	900	Yes	6/6	Splice, multimapping, strand
(Kang et al. 2015)	H. sapiens	Liver cells	485,684	Yes	1/9	Splice, multimapping, strand
(Danecek et al. 2012)	M. musculus	Brain cells	7389	No	2/2	Homopolymer, multimapping
(Gu et al. 2012)	M. musculus	Liver, adipose, and bone cells	253	No	3/3	Homopolymer, multimapping, extremity
(Lagarrigue et al. 2013)	M. musculus	Liver and adipose cells	63 and 188	No	4/6	Multimapping
(Cattenoz et al. 2013)	M. musculus	Brain cells	665	No	1/1	Splice, homopolymer, multimapping, strand, extremity
(Blanc et al. 2014)	M. musculus	Intestine and liver cells	500	No	1/1	Homopolymer, multimapping, extremity
(Chen et al. 2014)	R. macaque	Prefrontal cortex, cerebellum, muscle, kidney, heart, testis, and lung cells	31,250	Yes	1/1	Homopolymer, multimapping, extremity
Frésard et al. 2015	G. gallus	Whole embryo	40	Yes	2/8	—
Roux et al. (The present study)	G. gallus	Liver and adipose cells	11 and 17	Yes	3/8	—

↵a If “Yes”: individual genomic DNA information is used to account for potential private individual genomic polymorphisms. If “No”: potential private genomic polymorphisms are defined considering either genomic variant databases such as dbSNPs, or strain-specific consensus genomic sequence in the case of studies based on clonal mouse strains.
↵b Ratio between the number of biological replicates considered for reporting a candidate difference between DNA and mRNA as a true mRNA editing event and the total number of biological replicates available in the study for a given cell type.