Table 1 Drug combinations to prevent mitoxantrone resistance
Drug CombinationMitoxantrone-Resistant Cultures (n = 40)
Mitoxantrone + DMSO control98 ± 2%
Mitoxantrone + mechlorethamine74 ± 7%
Mitoxantrone + floxuridine64 ± 8%
Mitoxantrone + bleomycin28 ± 7%
Mitoxantrone + camptothecin13 ± 5%
Mitoxantrone + mitomycin C3 ± 3%
Mitoxantrone + rapamycin0%
Mitoxantrone + FK506 rapamycin analog0%
  • Error bars reflect the standard error of proportion.