Table 2 Association results for DBP-associated genes with gene-based P < 2.3×10−6
GeneP_GeneLocusSNPbP_CADScore
PositionReportedaIDFeatureP_SNP
CLCN61.24E-071p36NPPBrs12567136intronic1.15E-085
MTHFR1.42E-071p36.3MTHFRrs17367504intronic1.29E-087
HFE4.06E-076p22.1HFErs1799945exonic4.78E-087
HIST1H1T2.25E-076p22.1rs198846downstream3.80E-083
HIST1H4C1.46E-066p22.1rs198851downstream2.45E-073
C10orf1074.14E-0810q21.2C10orf107rs4590817intronic1.77E-092
ATP2B17.74E-0812q21.3ATP2B1rs2681472intronic3.90E-095
SH2B31.05E-1312q24SH2B3rs3184504exonic2.33E-148.10E-117
ACAD101.60E-0612q24rs659964intronic3.65E-071
ATXN21.07E-1312q24rs653178intronic1.64E-143.52E-087
CUX26.21E-0712q24rs7306529intronic4.87E-088.15E-074
FAM109A4.30E-0812q24rs37420043UTR2.15E-084.09E-062
ADAM1A2.06E-0612q24rs4766705intergenic2.05E-063
HECTD43.95E-1112q24rs11066188intronic3.06E-121.63E-074
MAPKAPK52.09E-0612q24rs3213628intronic2.09E-062.34E-063
NAA251.97E-1012q24rs17696736intronic2.80E-111.88E-073
PTPN118.89E-1012q24rs11066320intronic6.32E-111.82E-0710
TRAFD11.42E-1112q24rs17630235downstream2.92E-121.41E-084
ULK34.90E-0815q24.1ULK3rs12487upstream1.31E-083
COX5A7.86E-0815q24.1rs1133323downstream4.52E-084
CPLX31.64E-0915q24.1rs6495122downstream8.41E-105
CSK2.07E-1115q24.1rs1378942intronic3.47E-124
CYP1A22.48E-0915q24.1rs2470890exonic1.03E-095
C15orf178.39E-0815q24.1rs11856413upstream7.64E-080
LMAN1L3.17E-0915q24.1rs7162232intronic1.58E-092
MIR45131.96E-1115q24.1rs1378941intronic7.38E-121
MPI8.38E-0815q24.1rs7495739intronic5.02E-084
SCAMP22.80E-0815q24.1rs3765066intronic4.17E-093
FES1.69E-0615q26.1FESrs2521501intronic6.06E-075
ID12.0E-0620q11.21rs6058197upstream2.0E-065
MIR31932.0E-0620q11.21rs6058197upstream2.0E-061
  • a Genes reported in this region by the ICBP GWAS.

  • b The most associated SNP within the corresponding gene identified by gene-based analysis.