Table 1 Genes that affect touch sensitivity
Gene NameDescriptionConfirmed by Mutation
Transcription and translation related
 Y47H9C.7EIF2B β subnit homolog
TAF-5TAF (TBP-associated transcription factor) family
 taf-9TAF (TBP-associated transcription factor) family
nars-1Asparaginyl-tRNA synthetase
mog-5DEAH RNA helicase orthologous to PRP22 proteins.Yes
hars-1Aistidyl-tRNA synthetase (HisRS)
 F54D5.11TFIIE β subunit
 xrn-25′->3′ exonuclease
 C48E7.2RNAPol IIIC homolog
 D2085.3EIF2B ε subunit
 F55F8.3WD40-repeat-containing subunit of the 18S rRNA processing complex
F19F10.9Human SART1 homolog, U4/U6.U5 tri-snRNP−associated protein 1
Transcription and splicing control
 dmd-5Doublesex/mab-3 like
 mfap-1Microfibrillar-associated protein homolog, controls alternative splicing
Protein degradation
 pas-4Proteasome α-type seven subunit of the core 20S proteasome subcomplex
 rpn-1Non-ATPase subunit of proteasome 19S regulatory subcomplex
Calcium signaling
mca-3Plasma membrane Ca2+ ATPaseYes
 cal-2Calmodulin homolog
unc-43CaMKIIYes
Adhesion/focal adhesion complex
pxl-1Paxillin 1
pat-2aα-integrin subunitYes
pat-4aIntegrin-linked kinaseYes
pat-6aα-parvin (Actopaxin)Yes
unc-112aOrthologous to human mitogen-inducible gene-2Yes
unc-97aLIM domain-containing protein of the PINCH familyYes
 lam-2Laminin γ subunit
hmr-1Classical cadherin
Cytoskeleton and cell division
ifa-3Essential intermediate filament protein
 pfd-3Putative prefoldin, orthologous to human VBP1 that is required for α-tubulin synthesis
tag-170/txdc-9Thioredoxin domain-containing protein orthologous to human TXNDC9Yes
cdk-1Cyclin-dependent kinase, orthologous to CDC28 from S. cerevisiaeYes
fzy-1An ortholog of S. cerevisiae Cdc20, predicted to regulate metaphase-anaphase transitionYes
 knl-1Novel acidic protein, kinetochore component
 myo-3Myosin heavy chain A
Endo/exocytosis and synaptic functions
tom-1Tomosyn ortholog, binds SNAP25 (RIC-4)Yes
unc-11Clathrin-adaptor protein AP180Yes
cab-1Novel protein with a C-terminal motif weakly homologous to NPDC-1Yes
Mitochondria
 T20H4.523-kDa subunit of mitochondrial complex I
 Y37D8A.18Mitochondrial ribosomal protein, small
 F43E2.7Mitochondrial carrier nomolog
Signaling pathways
ptc-1Ortholog of Drosophila PATCHED (PTC) and human PTCHYes
 ptc-3Ortholog of Drosophila PATCHED (PTC) and human PTCH
goa-1Heterotrimeric G protein α subunit Go (Go/Gi class)Yes
kin-18TAO kinaseYes
let-502Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM kinase)Yes
let-92Catalytic subunit of protein phosphatase 2A (PP2A)Yes
 F47F2.1PKA homolog
 R03E1.2Renin receptor homolog
Others
 nsf-1NSF (N-ethylmaleimide sensitive secretion factor) homolog, may be required for ER to Golgi transport
 gfi-2GEI-4 (four) interacting protein
 glf-1UDP-galactopyranose mutase
 K12H4.4Signal peptidase complex subunit
pnk-1Pantothenate kinaseYes
 saps-1SAPS (phosphatase-associated) domain protein
vha-5Subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase)Yes
 crn-1Cell death−related 5′-3′ exonuclease, homologous to mammalian flap endonuclease 1 (FEN1)
cgt-3Ceramide glucosyltransferase, required for glycosphingolipid productionYes
sqv-3β-(1,4)-galactosyltransferase, required for cytokinesisYes
 T19B10.2Nematode-specific protein
 F26G1.2Nematode-specific protein
 C30B5.6Unknown protein
  • Gene names and their inferred homologies are listed. The genes were grouped according to their putative functions and/or the functions of their orthologs. tRNA, transfer RNA; ER, endoplasmic reticulum; SAPS, SIT4 phosphatase–associated protein.

  • a Five positive controls previously shown to affect touch sensitivity (Chen and Chalfie 2014).