Table 4 Gene Ontology term enrichment analysis for SNPs with P < 10−4
IndexLow-Glucose DietHigh-Glucose DietBoth Diets Pooled
GlucoseApoptosis(P = 0.016)Signal transduction(P = 0.020)Lipid transport(P = 0.030)
DNA binding TF activitya(P = 0.065)Enzyme activator activity(P = 0.039)Protein folding(P = 0.059)
Catalytic activity(P = 0.070)G-protein-coupled receptor(P = 0.068)
Plasma membrane(P = 0.076)Intracellular(P = 0.075)
Receptor activity(P = 0.079)
GlycerolMitochondrion organization(P = 0.044)DNA packaging(P = 0.052)RNA binding(P = 0.002)
Ion transport(P = 0.055)Structural constituent of ribosome(P = 0.052)Translation(P = 0.041)
Transporter activity(P = 0.056)Ribosome(P = 0.058)Neurotransmitter transporter act.(P = 0.065)
Endopeptidase activity(P = 0.084)Plasma membrane(P = 0.084)Nucleob(P = 0.072)
Transport(P = 0.087)Transport(P = 0.089)Behavior(P = 0.077)
Defense response(P = 0.090)
Endocytosis(P = 0.092)
Apoptosis(P = 0.096)
GlycogenStructural constituent of cytoskeleton(P = 0.051)Multicellular organismal development(P = 0.014)Lipid metabolic process(P = 0.030)
Molecular function(P = 0.095)Lipid transport(P = 0.087)
Transport(P = 0.099)
Mean wet weightProtein kinase activity(P = 0.010)Intracellular(P = 0.005)Cytoskeleton organization(P = 0.032)
Protein modification process(P = 0.025)Cytoskeleton organization(P = 0.009)Extracellular region(P = 0.035)
Response to stress(P = 0.031)Organelle development(P = 0.013)
RNA binding(P = 0.036)Endopeptidase activity(P = 0.033)
Cytosol(P = 0.054)Protein kinase activity(P = 0.039)
Intracellular protein transport(P = 0.086)Peptidase activity(P = 0.049)
Transcription factor binding(P = 0.089)Proteolysis(P = 0.033)
RNA binding(P = 0.072)
Cytoskeleton(P = 0.079)
Protein modification process(P = 0.095)
DNA-dependent transcription(P = 0.096)
ProteinExtracellular region(P = 0.008)Cell death(P = 0.010)Centrosome(P = 0.005)
Intracellular(P = 0.049)Sensory perception(P = 0.032)
DNA binding(P = 0.056)Cytoskeleton organization(P = 0.058)
Extracellular region(P = 0.061)Neurotransmitter transporter activity(P = 0.099)
Molecular function(P = 0.079)
TriglycerideMotor activity(P = 0.029)DNA binding TF activitya(P = 0.012)Transporter activity(P = 0.005)
Cell death(P = 0.033)Nucleus(P = 0.024)Centrosome(P = 0.016)
Cell communication(P = 0.043)Nucleic acid binding(P = 0.078)Cellular component(P = 0.017)
Intracellular(P = 0.091)DNA binding TF activitya(P = 0.025)
Transport(P = 0.026)
Ion transport(P = 0.079)
DNA binding(P = 0.091)
  • a “DNA binding TF activity” is “sequence-specific DNA binding transcription factor activity.”

  • b “Nucleo” is “nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process.