Table 2 QTL for cardiovascular risk factors in the DO mice at baseline and after dietary treatment
PhenotypeChrPeak LODPosition (Interval, Mb)Significant (P < 0.05)Previously Known QTL (Interval, Mb)KnownGene CandidatesRefs.
 Triglycerides911.351.4 (50.2−51.6)YesTrigq1 (40−70)ApoA5Suto and Sekikawa 2003
 Total cholesterol136.530.4 (28.7−43.8)NoHmgcs1 (20−100)HmgcrWelch 1996
 Glucose57.092.6 (86.3−99.0)NoBglu13 (84−110)Hnf1a, Pdx1Zhang et al. 2012
 Insulin195.458.6 (22.6−60.8)NoTanidd1 (36−61)Not DeterminedKim 2001
After diet
 Triglycerides125.897.6 (49.6−102.3)NoTglq2 (55−89)ApoBSrivastava 2006
 Total cholesterol97.548.3 (47.8−70.0)YesCq4 (15-50 Mb), Cq5 (32−66)ApoA4Suto and Sekikawa 2003
 Glucose125.770.9 (26.7−75.1)NoBglu15 (10−42)Adam17Zhang et al. 2012
 Insulin137.08.7 (5.7−10.4)NoNANANA
  • Clinical markers of cardiovascular disease were measured in study animals after 4 hr of fasting at both 6 and 24 wk of age. Baseline measures are from 6-wk-old fasted mice fed a synthetic diet. Measures at 24 wk of age, after diet, include mice on both the low-fat, high protein diet and the high-fat, cholic acid diet; diet was used as a covariate in the analysis. The statistic reported is log of the odds ratio (LOD). QTL, quantitative trait loci; DO, Diversity Outbred; NA, not available.