Table 1 Effects of high-protein, high-fat, cholic acid diets on cardiovascular risk factors in the DO mice
Baseline (AIN-76A)High ProteinHigh-Fat, Cholic Acid
nMeannMeannMean
Cholesterol, mg/dL27791.7 ± 25.112897.6 ± 31.5**136199.9 ± 68.6*,**
Triglycerides, mg/dL26259.5 ± 26.512857.7 ± 30.8**13632.3 ± 12.1*,**
Glucose, mg/dL257155.2 ± 43.8130190.5 ± 49.9137177.9 ± 45.1
Insulin, ng/mL2350.8 ± 0.41291.7 ± 1.1*1331.4 ± 0.7*
  • The values shown are means ± SD. Plasma clinical chemistries were measured at baseline (in 6-wk-old mice), after 2 wk on the synthetic-defined diet AIN-76A and with 4 hr fasting. Mice were transferred to one of two diets, either a high-fat, cholic acid diet or a low-fat, high protein diet, and maintained on these diets for 18 wk. Plasma clinical chemistries were measured again (in 24-wk-old mice) after diet treatment and with 4 hr fasting. Significant differences between the baseline diet measures and either diet treatment group (*, where P < 0.05) or significant differences between the two different diets after 18 weeks of diet treatment (**, where P < 0.05) are indicated.