Table 1 Germline transmission rates for NHEJ-mediated mutagenesis and ssODN-mediated HDR
Male CrossesFemale crossesTotal
ConstructHostssODNEmbryos% (No.) Founders% (No.) Progeny% (No.) Founders% (No.) Progeny% F1
DCC6-ew111818989 (17/19)14 (386/2802)57 (26/46)12 (536/4312)13
U6-enos-cas919253 (9/17)5.9 (68/1143)64 (9/14)16 (153/954)11
U6-evas-cas920183 (10/12)29 (362/1270)94 (32/34)49 (1765/3572)44
DCC6-MED27FRT827543 (3/7)20 (7/35)0 (0/5)0 (0/25)12
DCC6-hamw1118V58514 (3/22)2.7 (3/110)6.7 (1/15)6.7 (4/60)4.1
DCC6-dpnw1118V512611 (1/9)2.8 (2/72)13 (2/15)2.5 (3/120)2.6
DCC6-mγw1118V519115 (3/20)11 (11/100)5.9 (1/17)5.9 (5/85)8.6