Table 1 Genes that showed condition-specific interactions with query genes that were statistically significant after multiple test correction (q < 0.05)
QueryDrugInteractionSignificant Genes
HRQ1CPTNegativeASF1, CHL1, CLB5, CTF4, DCC1, DDC1, MMS1, MMS22, MRE11, PBY1, RAD17, RAD24, RAD52, RAD54, RAD55, RAD57, RAD59, RTT101, RTT109, SAE2
HRQ1CPTPositiveCYC8, GMH1, PDA1
HRQ1HUNegativeARP4, ASF1, BAS1, BMH1, BRE1, CLB5, ERG5, ERJ5, GCN1, GCN20, GET2, GNP1, HPC2, IRA2, LAT1, LGE1, LST4, MET18, MFT1, MKS1, MRC1, MRE11, NPR1, PBS2, PDB1, PDE2, PMR1, POL32, RAD52, RAD54, RAD55, RAD57, RIM21, RPL34B, RPS21B, RTF1, RTG3, RTT109, SDC1, SEC22, SEC66, SEC72, SGF73, SNX4, SPF1, SUA7, SWD1, SWD3, SWI4, SYC1, UBA3, UBP15, UBP6, URE2, VPS8, YTA7
HRQ1HUPositiveAIM21, APS3, ARO1, ARP7, BTS1, BUL1, CAP1, COQ2, CUE3, CYC8, CYT1, DCR2, FEN1, HOS2, MSS18, NGL2, PET130, THI6, YMR102C
HRQ1MMSNegativeDAL81, FKS1, GFD1, GFD2, GNP1, MMS2, MOG1, MPH1, MRE11, MSH4, PBY1, PET18, PHO5, POL32, RAD10, RAD18, RAD27, RAD59, REV1, REV3, REV7, RVS161, SAK1, SCS7, SRO9, STP1, TRS33, UBC13, VMA21, YGL081W, YSY6
HRQ1MMSPositiveCLB5, HST3, ILM1, KAP122, PMR1, SUR4
RTT107CPTNegativeAGE2, BCK1, BFA1, BUB2, CHS5, CLB2, CLB5, COG5, CRN1, CSG2, DCC1, DDC1, DEP1, ECM33, ELA1, ERV14, FET3, FKS1, FUN30, GAS1, HPC2, IRA2, IRC21, KEX2, LAS21, LEM3, LGE1, LTE1, MAK31, NCL1, OPI3, OST3, PAC1, PBY1, PEP8, PFA4, PMT1, PMT2, PPH21, PPH3, PPM1, PRE9, PSP2, RAD17, RAD24, RAD54, RAD55, RAD57, RAD61, RDH54, RDI1, REV7, RGA1, RRD2, RTF1, RTS1, RXT2, SAP30, SCS7, SEC22, SEC28, SLA1, SMI1, SMY1, SPF1, SRO9, STV1, SUR4, SWI4, TPK3, UBP14, VPS24, VPS27, VPS29, VPS35, VPS5, VPS8, VPS9, YDR061W, YJR088C, YLR426W, YPL150W, ZDS1
RTT107CPTPositiveAPQ12, ARP7, BUB1, BUB3, CDC28, CYC8, CYT1, DBF2, DPB4, ELC1, ELG1, ESS1, GAC1, GAL80, HDA1, IKI3, IPT1, JHD2, LIA1, MIP1, MKK2, MMS4, MRC1, MRT4, NAP1, NCS2, NFI1, NOP12, OAF1, PAP2, PEF1, POL32, PSY4, RAD27, RPL11B, RPL8B, RPS1B, RPS4A, RSC4, SAC3, SAM37, SCT1, SFL1, SGF29, SLC1, SMT3, SPT2, SSN2, TED1, TOP1, TRM10, TUB3, TUP1, UBX4, UFO1, YCR050C, YLR287C, YNR004W
RTT107HUNegativeAGE2, BAS1, BUB2, CRN1, DUG2, GCN1, IRA2, MAD2, NPR1, OXR1, PBS2, PSP2, SEC22, SER2, SLX9, SLY41, SPF1, SUR4, SWI4, URE2, YDL089W
RTT107HUPositiveAEP2, AIM26, ARO1, ARP7, BTS1, BUB3, BUD21, BUD6, BUL1, CDC48, CYC8, CYK3, CYT1, DBP1, ECM5, ERG6, HDA1, JNM1, LAG1, MET22, NAP1, NUP2, PEF1, PET130, PEX17, PMR1, POL30, PPM1, RIM101, RPN13, RPS1B, RPS28B, RPS30A, SCT1, SEF1, SPE3, SPT21, SSE1, THI6, TSA1, UBX4, UFO1
RTT107MMSNegativeBCK1, BFA1, CLB2, CRN1, DDC1, DUG2, FKS1, GFD1, GNP1, HRT1, IRC21, LSM7, LTE1, MBP1, MMS2, PAC1, POL30, PPM1, PTC2, RAD17, RAD18, RAD27, REV7, RTS1, SCS7, SLX9, SRO9, SRS2, STP1, TEL1, TSA1, UBC13, VMA21, YGL081W, YPL041C
RTT107MMSPositiveAIM29, APQ12, ARO1, BMH1, BTS1, CSM3, CYT1, DBF2, DOT1, ELC1, FEN1, GAL80, GSF2, HST3, ILM1, LGE1, MRC1, MSS18, NAM7, NPP1, PER1, RAD52, RMD11, ROT2, RPL8B, RPS1B, RPS4A, RSC4, SPT2, TEP1, TMA23, TOP1, TUB3, UFO1
SLX4CPTNegativeARP4, ASF1, CHL1, CIK1, CLB5, CSM3, CTF4, DCC1, DDC1, DIA2, GAS1, LAS21, LEM3, LGE1, MMS1, MMS22, PBY1, PMR1, PPH3, RAD17, RAD24, RAD52, RAD54, RAD55, RAD57, RAD59, RDI1, RTT101, RTT109, SAE2, SGF73, SRS2, STV1
SLX4HUNegativeAGE2, AIM32, ARL3, ARP4, BAS1, BMH2, BRE1, CLB5, COG5, CWH41, DDC1, ECM30, ERG5, ERJ5, FKH2, GCN1, GCN20, GEF1, GNP1, HCM1, HPC2, INP53, IRA2, LGE1, LST4, MDS3, MRE11, NPR1, OXR1, PBS2, PBY1, PDB1, PDE2, PFA4, PMR1, PRE9, PSP2, QCR10, QNQ1, RAD54, RAD55, RAD57, RPL41B, RPS11A, RTF1, SDC1, SEC22, SEC66, SGF73, SKY1, SNG1, SPF1, STV1, SUA7, SUR4, SWD1, SWD3, SWI4, SYC1, SYF2, UBP15, URE2, VPS27, YDR061W, YER064C, YPR063C, YSY6
SLX4HUPositiveAPS3, BTS1, BUL1, CAP1, CDC36, COQ2, CYT1, FEN1, HOS2, IMP2, MDM38, MFT1, MSS18, NGL2, PET123, PET130, RPL43A, RPN13, SCD6, SPT21, TAF9, TOP1, YDL176W, YIP3
SLX4MMSNegativeCKB1, DIA2, ENT4, ERV25, GFD1, GNP1, HST3, IMP2, MMS2, MPH1, PAC1, PET18, POL32, PPH3, PSY3, RAD18, RAD26, RAD27, RAD59, REV3, REV7, RRD1, SAE2, SAP185, SCS7, STP1, TOM7, TSR3, UBC11, UBC13, VMA21, YGL081W
SLX4MMSPositiveBUD14, DOT1, MSH4, NAM7, RPS21B
  • CPT, camptothecin; HU, hydroxyurea; MMS, methyl methane-sulfonate.