Table 4 Nucleotide divergence of lung and brain enhancers according to the human-chimpanzee-macaque sequence alignment
Sequence RegionDivergence (per kilobase)Selection
Human-SpecificNonhuman-SpecificNIP-Value Against Neutral Ref.P-Value of Proximal vs.Tele-
Brain enhancer
 Proximal5.3858.320.772 × 10−485 × 10−3
 Tele-5.3857.020.758 × 10−57
Lung enhancer
 Proximal5.4758.150.776 × 10−501 × 10−2
 Tele-5.3057.350.753 × 10−57
  • NI, neutrality index.