Table 1 Classification of sequenced strains
Functional DomainRelevant Genotype (CEN)ClassMutation Rate CanraFold Induction Canrn
msh2ΔNull6.7 (6.3−7.0) × 10−68930
MSH2 CENCEN WT8.0 (7.4−8.6) × 10−71609
Structural integritymsh2-A618VNull6.0 (5.2−6.8) × 10−67144
msh2-R657GNull6.2 (3.7−9.2) × 10−6872
msh2-L183PNull7.1 (6.1−8.1) ×10−69144
msh2-C195YNull8.5 (7.2−9.9) × 10−61172
msh2-C345FNull6.8 (5.8−7.8) × 10−68144
msh2-D621GNull9.6 (8.0−11.4) × 10−61272
msh2-P640TNull9.1 (7.9−10.3) × 10−611141
DNA bindingmsh2-R542LNull6.3 (5.4−7.3) × 10−68144
msh2-D524YNull4.8 (4.0−5.7) × 10−6672
ATPasemsh2-G688DNull7.8 (6.8−8.8) × 10−610144
msh2-G693RNull3.8 (3.2−4.4) × 10−65144
msh2-S695PNull5.0 (4.3−5.7) × 10−66144
msh2-S742FNull6.6 (5.9−7.5) × 10−68153
msh2-T743KNull8.7 (7.5−9.9) × 10−611144
msh2-G770RNull5.5 (4.8−6.3) × 10−67139
msh2-P689LPseudo-WT6.0 (4.9−7.2) × 10−71144
  • a Confidence limits in parentheses. WT, wild type.