Table 1 Sample characteristics
Discovery Cohort (n = 1904)Replication Cohort (n = 411)
VUMC (n = 1561)NU (n = 343)VUMC (n = 276)NU (n = 135)
Women, n (%)1048 (67%)250 (73%)193 (70%)100 (74%)
Age,a years46.73 ± 16.3149.85 ± 13.3756.82 ± 13.6841.98 ± 13.27
HGB, g/dL12.67 ± 1.5712.30 ± 1.5412.57 ± 1.6212.46 ± 1.66
HCT, %38.71 ± 4.2536.58 ± 4.4938.41 ± 4.4937.0 ± 4.91
RBC count, ×1012/L4.51 ± 0.544.28 ± 0.594.43 ± 0.614.33 ± 0.63
MCV, fL86.24 ± 6.3986.22 ± 6.1987.36 ± 6.5386.37 ± 6.17
MCH, pg28.22 ± 2.4928.99 ± 2.3828.56 ± 2.629.12 ± 2.41
MCHC, % or g/dL32.70 ± 1.2333.60 ± 0.6832.67 ± 1.1733.68 ± 0.75
  • VUMC, Vanderbilt University Medical Center; NU, Northwestern University; HGB, hemoglobin; HCT, hematocrit; RBC, red blood cell, MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration.

  • a The age is the age for median HGB. For the remaining traits, the age was within ±1 yr of the age at median HGB. In the association analyses for each trait, we used the corresponding median age for an individual. All trait values are mean ± SD.