Table 3 Genetic variants associated with the two PCs representing majority of variation in RBC traits
VectoraCHRSNPAllelesbGeneβ ± SEcP
PC116p13.3rs9924561T/GITFG31.53 ± 0.214E-13
PC216p13.3rs9924561T/GITFG32.97 ± 0.251E-31
PC2Xq28rs1050828A/GG6PD−1.97 ± 0.256E-15
  • PCs, principal components; CHR, chromosome; SNP, single-nucleotide polymorphism; HCT, hematocrit; HGB, hemoglobin; RBC, red blood cell; MCHC, MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin.

  • a PC1: HCT, HGB, and RBC count; PC2: MCV, MCH, and RBC count.

  • b The first allele is the minor allele.

  • c β = regression coefficient; for the additive effects of SNPs, the direction of the regression coefficient represents the effect of each extra minor allele.