Table 2 Genes in the screen
Gene NameShort DescriptionDegree of Suppression
BAP2High-affinity branched aminoacid permeaseStrong
ECO1Acetyltransferase required for Smc3p acetylation during the establishment of sister chromatid cohesionStrong
HTB1Histone H2BStrong
CDC34Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complexStrong
CHD1Chromatin remodellerStrong
CRM1Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleusStrong
MOB1Component of the mitotic exit networkStrong
DDC1Member of the 9-1-1 clamp essential for the DNA damage responseStrong
CST6Basic leucine zipper (bZIP) transcription factorStrong
MPH1Helicase that functions in an error-free DNA damage bypass pathwayStrong
YKL044wGene of unknown functionStrong
SIS2Negative regulatory subunit of the protein phosphatase 1 Ppz1Strong
UBC11Ubiquitin-conjugating enzymeStrong
NHP6AHigh-mobility group non-histone chromatin proteinStrong
TPT1tRNA 2’-phosphotransferase, catalyzes the final step in yeast tRNA splicingStrong
TAF3TFIID subunit involved in transcription initiationStrong
RTT103Involved in transcription terminationMedium
SRL3Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutationMedium
RTT109Histone H3 acetylaseMedium
GID8Member of a ubiquitin ligase that carries out poly-ubiquitination.Medium
GIS2Protein with seven cysteine-rich CCHC zinc-finger motifsMedium
RTT106Histone chaperoneMedium
YOL114cGene of unknown functionMedium
IRC13Null mutant displays increased levels of spontaneous Rad52 fociMedium
NUP1Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAsWeak
PPS1Protein phosphatase with specificity for serine, threonine, and tyrosineWeak
UBP14Ubiquitin-specific proteaseWeak
NSE3Essential subunit of the Mms21-Smc5-Smc6 complexWeak
PAB1Poly(A) binding protein, part of the 3′-end RNA-processing complexWeak
DAM1Essential subunit of the Dam1 complex, involved in kinetochore movementWeak
CPD1Cyclic nucleotide phosphodiesteraseWeak
UBP7Ubiquitin-specific protease that cleaves ubiquitin-protein fusionsWeak
RPB4Subunit of RNA polymerase involved in 3′-end RNA processing and exportWeak
RFX1Major transcriptional repressor of DNA-damage-regulated genesWeak
HAS1ATP-dependent RNA helicase, localizes to nuclear poreWeak
CNM67Component of the spindle pole body outer plaqueWeak