Table 1 Mammalian Orthologs of Drosophila Genes Affected by Mutant SOD1 Expression
Probe Set IDFly Gene5-Day-Old Flies Fold Change45-Day-Old Flies Fold ChangeCell Type Expression of G85ROrthologOrganismFold ChangeTissue for Microarray (study ref.)
1637801_atSepia1.12a−1.01aMNGlutathione S-transferase omega 1mouse−3.02Motoneurons (Kirby et al. 2005)
1631055_atcAMP-dependent protein kinase 1−1.20a−1.26aMNProtein kinase, cAMP- dependent, catalytic, alpha (Prkaca)mouse−2.11Astrocytes (Ferraiuolo et al. 2011)
−1.23a−1.45MN + glia
1631534_atSulfateless−1.87−1.71MNN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2human1.52Motoneurons
−2.39−2.37Glia1.07Ventral horn (Jiang et al. 2005)
1635607_atCG31742−1.74−1.81MNProteasome (prosome, macropain) subunit, beta type, 5human1.2Motoneurons
−1.94−1.68Glia1.42Ventral horn (Jiang et al. 2005)
1623503_atSlamdance1.02a−1.74MNAlanyl (membrane) aminopeptidasehuman0.61Motoneurons
−1.14a−2.02Glia0.57Ventral horn (Jiang et al. 2005)
  • Mammalian orthologs of Drosophila genes that also have been identified as differentially regulated in other microarray experiments. MN, motoneurons.

  • a Not statistically significant at a Benjamini-Hochberg corrected P value of >0.05.