Table 1 High-confidence PDZ domain-encoding genes in border cell migration identified by RNAi knockdown
GenePutative Vertebrate HomologaOther Domains PresentbNo. of Hits / Total LinescKnown Role in Cell Migrationd
bazookaPARD3 (PAR3)Oligomerization domain2 / 2Pinheiro and Montell (2004)e
Nakayama et al. (2008)f
big bangPDZD2None2 / 3
CASK orthologCASKGuanylate kinase domain2 / 3
L27 domain
Protein kinase, catalytic domain, inactive
SH3 domain
CG5921Harmonin / USH1CNone2 / 2
CG6498MAST2Domain of unknown function3 / 3
Protein kinase, catalytic domain
CG6509DLG5Guanylate kinase domain2 / 3Smolen et al. (2010)f
Src homology 3 domain
Gef26RAPGEF2 / PDZ-GEF1Cyclic nucleotide-binding domain3 / 3Huelsmann et al. (2006)e
Guanine-nucleotide dissociation stimulator (RasGEF)
Ras association domain
Ras-like guanine nucleotide exchange factor, N-terminal
Lap1LRRC7 / ERBB2IPLeucine-rich repeats2 / 2
LIMK1LIMK1LIM zinc-binding domain2 / 3Zhang et al. (2011)e
Protein kinase, catalytic domainNishita et al. (2005)f
par-6PARD6 (PAR6)PB1 domain3 / 3Pinheiro and Montell (2004)f
PatJINADL / MPDZL27 domain2 / 3Shin et al. (2007)f
RimRIMS2C2 domain2 / 3
stardustMPP5 (PALS1)Guanylate kinase domain2 / 3
L27 domain
Src homology 3 domain
veliLIN7A / LIN7B / LIN7CL27 domain2 / 2
  • a Putative homologs were found using NCBI Homologene and UniProt.

  • b Protein domains were identified using NCBI Conserved Domains Database and Interpro.

  • c Number of RNAi lines that resulted in a migration defect out of all lines tested.

  • d Cited references describe the Drosophila gene or its homologs.

  • e Pertains to studies in Drosophila.

  • f Pertains to the mammalian homolog.