Table 1 

Summary of the significant eQTL

GeneChrStart, MbEnd, MbSize, MblogPTypeLow StrainsHigh StrainsStatus
A. High response to infection
 Gsdmachr1198.46799.5281.06120.768cisNANAN
 LOC675467chr1420.23920.6480.40912.766cisABDGCS
EFH
 Ifi27l2achr12107.030107.7200.69012.655cisGABCDS
EFH
 ENSMUSG00000052976chr1928.68130.1251.44412.544cisFHABCP
DEG
 Dstchr133.32635.1801.85411.943cisADEFHBCGF
 Sik1chr1734.94644.1969.25011.529cisBCEFADGHP
 AK144717chr193.1973.8190.62210.535cisNANAN
 NAP070792-1chr7114.496118.0403.54410.436transNANAN
 Senp5chr1629.63731.5711.93410.19cisAFGBCDF
EH
 Kcmf1chr668.50969.8091.3009.771cisFABCDEGHS
B. Low response to infection
 Bmpr2chr159.49562.7723.27715.071cisABCFGF
DEH
 Tcf7l1chr670.21576.1375.92214.416cisFDGABCF
EH
 AK078430chr3131.067133.9982.93113.914cisFGABCP
DEH
 Thnsl2chr667.95970.6682.70912.832cisGDABCS
EFH
 AK153595chr175.2207.3522.13212.013cisGDABCS
EFH
 D930030005Rikchr773.67677.8034.12711.056cisABCFGP
DEH
 BC022687chr12112.813114.4541.64111.017cisBDCAEFS
GH
 Sh3gl3chr787.80891.0223.21410.721cisABCFGS
DEH
 Clec16achr166.32810.8734.54510.446cisBACDES
FGH
 Pde7achr326.12627.7691.64310.358cisABCFF
DEGH
 1190007I07Rikchr1076.09384.8378.74410.011cisNANAN
  • An eQTL support interval (NCBI37/mm9) is defined by a 1.5 LOD drop from the maximum LOD score at the marker with the maximum –log10 P-value (logP column). Type indicates whether the eQTL was on the same chromosome as the gene (cis) or not (trans). The low strain column indicates those strains that had lower allele effects relative to the strains in the high strain column. Strains were one of A (A/J), B (C57BL/6J), C (129S1/SvImJ), D (NOD/ShiLtJ), E (NZO/HILtJ), F (CAST/EiJ), G (PWK/PhJ) and H (WSB/EiJ) or NA indicating not applicable. The status column indicates whether the allele effects for that eQTL were consistent (S) with the allele's effects in inbred founder strains, partially consistent (P), not tested (N), or inconsistent (F). eQTL, expression quantitative trait loci.