Table 2  Summary of BXD linkage and human association of the syntenic locus
Mouse ChromosomePhenotypeMax LODHuman Markers TestedMaximum Associated MarkerAssociation q-valueHuman Genes
14110063.88476rs13304690.0820GPC5
1a101442.721343rs7900220.1360EFHD1
ALPI
101472.48CHRND
CHRNG
2101442.43635rs60773090.1510ANGPT4
RSPO4
FAM110A
3104982.92335rs168281270.2240NLGN1
11c103472.41333rs98924270.2695ELAC2
18b105002.29639rs118758450.3970DCC
1b101462.53509rs105159880.4040ZCCHC2
11a100783.36361rs98851720.6060SLIT3
6100422.91244rs23750160.6230SVOP
10105002.21163rs73974700.6630TBK1
XPOT
18a101472.09704RS26848470.7040DTNA
11b100423.89319RS98924270.9800GRB7
ERBB2
NEUROD2
TCAP
STARD3
PNMT
PPP1R1B
13104982.21154rs77166000.9950MRPS30
105001.96
105011.96
  • All loci with “suggestive” linkage to at least one BXD ethanol-induced ataxia phenotype are listed. The first three columns describe the BXD linkage (see Table 1 to decipher phenotype code). If a mouse chromosome has more than one linkage signal, the loci are differentiated with a letter after the chromosome number. The next four columns describe the association results of the human syntenic locus; q-values refer to the marker. All genes that map within 100 kb of the maximum associated marker are listed.