Table 1  Description of the seven MHC founding haplotypes defined in the Mauritian cynomolgus macaque population by means of 17 microsatellites
MicrosatellitesThe Seven Founding Haplotypes of the Mauritian Macaque Population
H1H2H3H4H5H6H7
D6S2972129121123121121123123
D6S2970303 (307a)307 (303a)295315311353311
D6S2854b173−193173−193173−193173−193−197213173−193−197173−193
D6S2704163163145147153147161
D6S2847321321321321321323323
C4-2-25235237235235235235235
MICA203200200200206194203
D6S2793276268246246246246278
D6S2782324343337341341337337
D6S266913011214313011097110
D6S2892208202206202205208202
DRACA237268272266266268270
D6S2876215211217211204211211
D6S2747208203Null or 194c191206210191
D6S2745299311303303299299303
D6S2771398399399395398399395
D6S2741266276256258268272258
  • a Most of the haplotypes H1 and H2 have the alleles 303 and 307, respectively. However, the allele 307 is observed also in 10 of 273 H1 haplotypes and the allele 303 is also present in 19 of 186 H2 haplotypes. Because the microsatellite D6S2970 is based on a tetranucleotide repeat, we have interpreted the allele variations in haplotypes H1 and H2 as consequences of mutations.

  • b As for the microsatellite D6S2854, fragments of respective lengths 173 and 193 bp were amplified in all animals but homozygous H5/H5. In these animals a single 213-bp fragment was amplified. The 197-bp allele was observed only in animals with haplotype H4 or H6.

  • c A fragment of 194 bp was amplified weakly from all DNA samples from H3/H3 homozygous animals. However, this fragment was never obtained in the H3 heterozygous animals.