Table 5  Regions of CRUK 972, CBS 356, CBS 2777, Nott 138, 141, 143, and 145 showing copy number variation
StrainChromosomeRearrangementStart BreakpointFinish BreakpointSize (kb)Comments
NOTT 141IDuplication3031645–30318343211591–3211839180
NOTT 143, NOTT 145IDuplication3031645–30318343233014–3233274201
NOTT 138IDeletion124442–124568124866–1250010.3No annotated gene
NOTT 138IDuplication5499761–55000815500384–55020542Part of a galactosidase (mel1) gene
CRUK 972IITriplication1598396–1610931603682–162084219Dgdh repeats
NOTT 141, NOTT 143, CBS 2777IIDuplication2036773–20372312041544–20418134Includes ccc2-Menkes disease protein
NOTT 138, NOTT 141, NOTT 143, NOTT 145, CBS 2777IIDeletion356108–356292359569–3600003SPBC1271.07E, SPBC1271.08E, mug96
NOTT 138IILoss of copy number2114026–21155662116080–21164070.5Mating type locus
CBS 356, NOTT 141, NOTT 143, NOTT 145, CBS2777IIIdeletion1493999–14944801499706–15003115Deletion of pseudogene SPCC188.10c-1
NOTT 141, NOTT 143, NOTT 145 (4 copies)IIIDuplication1893874–18942051926082–192668932SPCC737.05-08, hmt1 (ABC transporter involved in response to Cd++), mug24, sly1
NOTT 141, NOTT 143, NOTT 145IIIDuplication1174389–11745181180220–11808726Includes SPCC4B3.01-1 putative 3-mercaptopyruvate sulfurtransferase
NOTT 141, NOTT 143IIIDuplication381359–383288383347–383709SPCC1682.06
NOTT 138IIIDeletion969398–970117971646–9719401No annotated gene
CBS 2777, NOTT 138, NOTT 141, NOTT 143, NOTT 145IIIDeletion1645637–16460961648511–16492312Deletion of pseudogene SPCC663.07c-1
CBS 356, CBS 2777, NOTT 138, NOTT 141, NOTT 143IIICNV polymorphic2108532–21093342109565–21110261wtf22; listed as a pseudogene
  • The indicated strains were analyzed by comparative genome hybridization using Agilent 4 × 44K ChiP-on-chip arrays, and the indicated regions of copy number variation were detected.