Table 4  Association results of NINJ2 in the GEOS Study
Previously Reported VariantBest SNP within the Gene
No. of SNPsaVariantEffect/Noneffect AlleleOR (95% CI)PbVariantEffect/Noneffect AlleleOR (95% CI)PbEmpirical Pc
EAd70rs12425791A/G0.96 (0.76, 1.21)0.74rs12229103A/C1.34 (0.90, 2.00)0.150.95
rs11833579A/G1.00 (0.81, 1.24)0.99
AAd70rs12425791A/G1.02 (0.73, 1.42)0.91rs11063749T/C0.74 (0.60, 0.93)0.0080.27
rs11833579A/G1.04 (0.80, 1.35)0.76
  • Abbreviations: CI, confidence interval; OR, odds ratio; P, association P value.

  • a Number of SNPs within the gene that were either directly genotyped (SNP call rate > 95% and HWE P > 1.0 × 10−7 in either European or African ancestry) or imputed (imputation dosage r2 > 0.3).

  • b Nominal P was obtained by t-statistics in the logistic regression.

  • c Empirical P was obtained by permutations as described in Materials and Methods.

  • d European ancestry (EA) and African ancestry (AA) are defined based on multidimensional scaling (MDS) analysis.